Navegando por Palavras-chave "Esophagitis, peptic"

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    Effect of the celexoxib in microscopic changes of the esophageal mucosal of rats induced by esofagojejunostomy
    (Colégio Brasileiro de Cirurgiões, 2014-06-01) Lima, Austry Ferreira de; Lourenço, Laércio Gomes [UNIFESP]; Matos, Delcio [UNIFESP]; Rodrigues, Célio Fernando de Sousa; Universidade Federal de São Paulo (UNIFESP); Universidade Federal de Alagoas Department of Morphology
    OBJECTIVE:To evaluate the protective effect of celecoxib in the esophageal mucosa in rats undergoing esofagojejunostomy.METHODS:Sixty male Wistar rats from the vivarium of the University of Health Sciences of Alagoas were used for the experiment. The animals were divided into four groups: Group I, 15 rats undergoing esofagojejunostomy with the use of celecoxib postoperatively; Group II, 15 rats undergoing esofagojejunostomy without the use of celecoxib; Group III, 15 rats undergoing celiotomy with bowel manipulation; and Group IV, 15 rats without surgery and using celecoxib. The observation period was 90 days. After the death of the animals, the distal segment of the esophagus was resected and sent for microscopic analysis.RESULTS:esofagojejunostomy caused macroscopic and microscopic esophagitis. Esophagitis was equal in both groups I and II. In groups III and IV esophageal lesions were not developed.CONCLUSIONS:celecoxib had neither protective nor inducing effect on esophagitis, but had a protective effect on dysplasia of the animals of group I.
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    Esofagite de refluxo em crianças: estudo histológico e morfométrico
    (Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE Colégio Brasileiro de Cirurgia Digestiva - CBCD Sociedade Brasileira de Motilidade Digestiva - SBMD Federação Brasileira de Gastroenterologia - FBGSociedade Brasileira de Hepatologia - SBHSociedade Brasileira de Endoscopia Digestiva - SOBED, 2002-04-01) Mader, Ana Maria Amaral Antonio [UNIFESP]; Alves, Maria Teresa de Seixas [UNIFESP]; Kawakami, Elisabete [UNIFESP]; Patricio, Francy Reis da Silva [UNIFESP]; Fundação ABC Faculdade de Medicina Departamento de Patologia; Universidade Federal de São Paulo (UNIFESP)
    Background - Gastroesophageal reflux disease is a frequent cause of morbidity in childhood, including esophagitis and recurrent respiratory symptoms; however histological and morphometric studies in esophageal biopsies of children are scarce. Aim - To study histological and morphometric findings in children with reflux esophagitis. Patients and Methods - We studied 26 esophageal biopsies of children (mean age: 4.1 years ± 3.4) with reflux esophagitis, which prevailed in boys (84.6%); post-prandial vomiting (76.9%) and repetitive bronchopneumonia (38.5%) were the most frequent symptoms. The diagnosis was made by X-ray in 18, by pH evaluation in 5 and by scintilography in 3 patients. The control group was formed by seven children without reflux symptoms who died from meningococcemia or congenital heart malformation (mean age: 2.5 years ± 2.3). Histological variables were studied by hematoxylin-eosin and periodic acid of Schiff stain, inflammatory infiltrate, epithelial and basal layer thickness, papillary length and its ratio with the thickness of the epithelium. Morphometry was performed at a digital system connected to pro-image software. Student's t test, Mann-Whitney test, Fisher and Pearson's correlation methods were used for the statistical analysis. Results - Epithelial and basal zone thickness, papillary length and its rate with thickness of epithelium, among the reflux group patients were higher than the control group. Eosinophils, neutrophils and balloon cells were not observed in the control group. Intraepithelial capillaries occurred in 11 cases in the reflux group (mean diameter: 59 mum). Conclusion - Epithelial and basal zone thickness, papillary length and its ratio with thickness of epithelium, resulted greater in the gastroesophageal reflux group than in the control group. There was a direct correlation between thickness of epithelium, basal zone thickness and papillary length, showing increased epithelial cell turnover. Eosinophils, neutrophils and balloon cells were observed only in patients with gastroesophageal reflux, thus serving as specific markers of this disease.