Navegando por Palavras-chave "EORTC QLQ-C30"

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    Determinants of quality of life in advanced cancer patients with bone metastases undergoing palliative radiation treatment
    (Springer, 2013-11-01) Lam, Kinsey; Chow, Edward; Zhang, Liying; Wong, Erin; Bedard, Gillian; Fairchild, Alysa; Vassiliou, Vassilios; El-Din, Mohamed Alm; Jesus-Garcia, Reynaldo [UNIFESP]; Kumar, Aswin; Forges, Fabien; Tseng, Ling-Ming; Hou, Ming-Feng; Chie, Wei-Chu; Bottomley, Andrew; Univ Toronto; Univ Alberta; Bank Cyprus Oncol Ctr; Tanta Univ Hosp; Universidade Federal de São Paulo (UNIFESP); Reg Canc Ctr; St Etienne Univ Hosp; Natl Yang Ming Univ; Kaohsiung Med Univ Hosp; Natl Taiwan Univ; European Org Res Treatment Canc
    Assessment of health-related quality of life (HRQOL) is critical to effective delivery of palliative care in patients with advanced cancer. the current study analyzes relationships between baseline social determinants of health and medical factors, and self-reported HRQOL in patients with bone metastases receiving palliative radiotherapy.Advanced cancer patients referred for radiotherapy treatment of bone metastases completed the EORTC QLQ-C30 questionnaire in multiple outpatient clinics internationally. Demographics and social determinants were collected as baseline information. Univariate and Bonferroni-adjusted multivariate linear regression analyses were used to detect significant correlations between baseline determinants and different HRQOL domains.Karnofsky Performance Status (KPS) was correlated with better physical (p = 0.0002), role (p < 0.0001), emotional (p < 0.0001), and social (p < 0.0001) functioning, and global health scores (p = 0.0015) and predicted lower symptom scores for fatigue (p < 0.0001), pain (p < 0.0001), appetite loss (p < 0.0001), and constipation (p < 0.0001). Increased age was predictive of better social functioning (p < 0.0001) and less insomnia (p = 0.0036), higher education correlated with better global health status (p = 0.0043), and patients who were employed or retired had improved physical functioning (p = 0.0004 and p = 0.0030, respectively) and less financial challenges compared to patients who were unemployed (p = 0.0005).Baseline KPS had the greatest influence on EORTC QLQ-C30 domain scores. Age, education level, and employment status had significant impacts, although on fewer domains. Further studies that investigate baseline determinants are worthwhile to clarify relationships in order to care for patients more effectively at the end of life.
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    An international prospective study establishing minimal clinically important differences in the EORTC QLQ-BM22 and QLQ-C30 in cancer patients with bone metastases
    (Springer, 2012-12-01) Zeng, Liang; Chow, Edward; Zhang, Liying; Tseng, Ling-Ming; Hou, Ming-Feng; Fairchild, Alysa; Vassiliou, Vassilios; Jesus-Garcia, Reynaldo [UNIFESP]; El-Din, Mohamed A. Alm; Kumar, Aswin; Forges, Fabien; Chie, Wei-Chu; Bedard, Gillian; Bottomley, Andrew; Univ Toronto; Natl Yang Ming Univ; Kaohsiung Med Univ Hosp; Cross Canc Inst; Bank Cyprus; Universidade Federal de São Paulo (UNIFESP); Tanta Univ Hosp; Reg Canc Ctr; St Etienne Univ Hosp; Natl Taiwan Univ; EORTC Headquarters
    Quality of life (QOL) is frequently an endpoint in clinical trials involving patients with advanced cancer. Statistical significance of minimal differences can be achieved with sufficient sample size, yet the actual clinical relevance is unknown. the purpose of this study was to establish the minimal clinically important difference (MCID) for the European Organisation for Research and Treatment of Cancer (EORTC) bone metastases module (EORTC QLQ-BM22).Patients with bone metastases across seven countries were prospectively enrolled in a trial validating the EORTC QLQ-BM22 and completed the QLQ-BM22 and core measure (QLQ-C30) at baseline and 1-month follow-up. MCIDs were calculated for each QOL scale for both improvement and deterioration using both an anchor- (performance status) and distribution-based approach.A total of 93 patients completed both baseline and follow-up QOL and had recorded performance status at both intervals. Statistically significant meaningful differences were seen in seven scales. There were improvements of 30.5 (95 % confidence interval, 9.0 to 52.0), 20.1 (7.1 to 33.2), 30.5 (13.8 to 47.3) and 19.6 (5.0 to 34.3) in the pain, painful site, painful characteristic and functional interference scales, respectively, demonstrated clinical relevance. Decreases of 12.4 (0.3 to 24.6), 22.4 (11.8 to 32.9) and 13.5 (1.9 to 25.1) were required to represent clinically relevant deterioration in emotional functioning, global health status and financial issues, respectively. Minimal differences for improvement were closest to 0.5 standard deviations (SD) while for deterioration, closer to 0.3 SD on the QLQ-BM22.Identification of requirements for clinical significance can assist in determining the relevance of QOL changes after treatment and in sample size determination in future trials. Our study is limited by the small sample size. Future studies should continue to determine MCID and confirm our findings using a variety of appropriate anchors and in a larger sample.
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    Predictive factors of overall quality of life in advanced cancer patients using EORTC QLQ-C30
    (Expert Reviews, 2014-02-01) Cramarossa, Gemma; Zeng, Liang; Zhang, Liying; Tseng, Ling-Ming; Hou, Ming-Feng; Fairchild, Alysa; Vassiliou, Vassilios; Jesus-Garcia, Reynaldo [UNIFESP]; El-Din, Mohamed A. Alm; Kumar, Aswin; Forges, Fabien; Chie, Wei-Chu; Sahgal, Arjun; Lam, Henry; Pulenzas, Natalie; Chow, Edward; Univ Toronto; Natl Yang Ming Univ; Kaohsiung Med Univ Hosp; Cross Canc Inst; Bank Cyprus; Universidade Federal de São Paulo (UNIFESP); Tanta Univ Hosp; Reg Canc Ctr; St Etienne Univ Hosp; Natl Taiwan Univ
    Objective: To identify which domains/symptoms from the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) were predictive of overall quality of life (QoL) in advanced cancer patients. Methods: Four hundred and forty seven patients with brain metastases or bone metastases from seven countries were enrolled with regression analysis to determine the predictive value of the QLQ-C30 functional/symptom scores for patient reported overall QoL (question 30), overall health (question 29) and the global health status domain (questions 29 and 30). Results: Worse role functioning, social functioning, fatigue and financial problems were the most significant predictive factors for worse QoL. in the bone metastases subgroup (n = 400), role functioning, fatigue and financial problems were the most significant predictors. in patients with brain metastases (n = 47), none of the EORTC domains significantly predicted worse QOL. Conclusion: Deterioration of certain QLQ-C30 functional/symptom scores significantly contributes to worse QoL, overall health and global health status.