Navegando por Palavras-chave "Drogas na gravidez"

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    Efeitos do Uso Crônico de Acetaminofeno na Prenhez da Rata
    (Federação Brasileira das Sociedades de Ginecologia e Obstetrícia, 1999-03-01) Andalaft Neto, Jorge; Simões, Manuel de Jesus [UNIFESP]; Evêncio Neto, Joaquim [UNIFESP]; Kulay Júnior, Luiz [UNIFESP]; UNISA Faculdade de Medicina de Santo Amaro; Universidade Federal de São Paulo (UNIFESP)
    Purpose: to evaluate the effects of acetaminophen on the pregnancy of female albino rats. Methods: forty pregnant rats were separated into four groups. All the animals received daily by gavage 1 ml of acetaminophen solution from the first day (day zero) until the 20th day of pregnancy: group I - only distilled water (control); groups II, III and IV, respectively, 125, 500 and 1,500 mg/kg body weight of acetaminophen dissolved in distilled water. The animals were weighed on days 0, 7, 15 and 20 of pregnancy. Results: our results showed that the rats that received the medication presented a reduction in weight when compared to the control group. The incidence of reabsorption of the embryos was 2.0, 3.5 and 7.0 times higher than in the control, in groups II, III and IV, respectively. Groups GII and GIV showed a clear reduction in the weight of the concepts. In GIV there was a 50% reduction in weight increase of fetuses and placentas when compared to the control, and 15.7% of external malformations were also found. Conclusions: the continuous use of acetaminophen should be avoided at doses higher than 70 mg/kg per during pregnancy.
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    Efeitos do uso crônico do difosfato de primaquina sobre a prenhez da rata
    (Federação Brasileira das Sociedades de Ginecologia e Obstetrícia, 1998-10-01) Azevedo, Eliel Nina de [UNIFESP]; Santos, Alessandra Silva; Mendes, Eliane Terezinha Rocha; Simões, Manuel de Jesus [UNIFESP]; Kulay Júnior, Luiz [UNIFESP]; Universidade Federal do Pará Departamento de Assistência Materno-Infantil; Fundação Universitária do ABC Faculdade de Medicina Departamento de Saúde Materno-Infantil; Universidade Federal de São Paulo (UNIFESP)
    Purpose: to evaluate the chronic action of primaquine diphosphate on the pregnancy of female albino rats. Methods: sixty pregnant female rats, separated into six groups, were used. Group I received daily, by gavage, 1 ml of distilled water from day zero to the 20th day of pregnancy (control group). The female rats of the other groups also received daily, by gavage, during the same period of time the volume of 1 ml containing gradually concentrated primaquine diphosphate solution: 0.25 mg/kg, group II; 0.50 mg/kg, group III; 0.75 mg/kg, group IV; 1.5 mg/kg, group V and 3.0 mg/kg, group VI. The maternal weights were considered on day zero and on the 7th, 14th and 20th days of pregnancy, when the matrices were sacrificed. Results: the results showed that primaquine diphosphate, in the used doses, did not interfere with none of the following variables: maternal weight, newborn weight, medium individual weight of fetuses, weight of the group of placentas and medium individual weight of the placentas, implantation number, number of placentas and number of fetuses, when compared with the control group. Also there was no case of reabsorption, malformation, maternal mortality or intrauterine death, in any of the studied groups. Conclusion: in the conditions of the study there were no contraindications for the continuous use of primaquine diphosphate during the pregnancy of the female rat.
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    Efeitos do uso crônico do tramadol sobre a prenhez da rata albina
    (Federação Brasileira das Sociedades de Ginecologia e Obstetrícia, 2001-03-01) Santos, Alexandra Silva; Azevedo, Eliel Nina de [UNIFESP]; Oliveira-filho, Ricardo Martins; Simões, Manuel de Jesus [UNIFESP]; Kulay Júnior, Luiz [UNIFESP]; Universidade Federal do Pará Faculdade Medicina Departamento de Obstetrícia e Ginecologia; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)
    Purpose: to examine the effects of tramadol hydrochloride on rat pregnancy. Methods: five groups of 10 pregnant albino rats each were treated from the 1st up to the 20th day of pregnancy as follows: GI = intact controls; GII = controls which received 0.5 ml of distilled water (drug vehicle) once a day by gavage; GIII, GIV and GV = groups treated respectively with 6.7, 20.1 or 45.6 mg/kg of tramadol hydrochloride once a day by gavage in a final volume of 0.5 mL. Body weight gain was monitored by weighing at the beginning and on the 7th, 14th and 20th day of pregnancy. At term the animals were killed under deep ether anesthesia and the following parameters were evaluated: number of implantations, of resorptions, of viable fetuses and of placentae; presence of major malformations; maternal and fetal mortality and weights of fetuses and placentae. Results: tramadol significantly affected maternal body weight gain, this effect being more apparent in groups IV and V (mean reductions of weight gain of 41 and 56%, respectively). In group III the weight gain was affected more at days 7 and 14 (33% mean gain reductions) than at day 20 (19%). Drug treatment affected significantly and in a dose-dependent fashion the following parameters: individual weight of fetuses (GV = -39.2%), offspring weight (GIV = -51.7%; GV = -44.2%), number of placentae (GIV = -28.4%; GV = -11.6%), individual weight of placentae (GV = -10%) and the total weight of placentae (GIV = -28.4%; GV = -16.8%). Though among the treated animals there was an increase in resorptions and deaths at birth, these events were not significantly different from those found in controls. Conclusions: Tramadol showed definite deleterious effects on albino rat pregnancy, and these effects were exerted not only on the maternal but also the on fetal organisms. Overall, the effects were more pronounced at the 14th than at the 20th day of pregnancy, thus suggesting that the organogenic phase of the fetus is more susceptible than its initial (embryogenic) or final (term) phases. The results call attention to the care which is to be taken when the use of this opioid is considered during pregnancy.