Navegando por Palavras-chave "Dapsona"

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    Dapsona como alternativa no tratamento de urticária crônica não responsiva a anti-histamínicos
    (Sociedade Brasileira de Dermatologia, 2008-10-01) Pires, Juliana Soares [UNIFESP]; Ue, Ana Paula Fusel De [UNIFESP]; Furlani, Wellington De Jesus [UNIFESP]; Souza, Patrícia Karla De [UNIFESP]; Rotta, Osmar [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    BACKGROUND: Chronic urticaria is a dermatosis that negatively interferes in quality of life of affected individuals. The classic treatment with antihistamines is many times ineffective. OBJECTIVE: To evaluate the efficacy and safety of using dapsone in the treatment of chronic urticaria non-responsive to antihistamines. METHODS: A retrospective study was carried out by reviewing the medical charts of patients seen at an outpatient s clinic specialized in urticaria, between November 1996 and March 2007. RESULTS: Twenty patients with difficult to control chronic urticaria and who were treated with 100 mg/day of dapsone were evaluated. High doses of antihistamines were maintained and associated with dapsone. Antihistamines alone did not control symptoms. Fourteen patients (70%) presented good results, observed in the reduction or disappearance of lesions as well as in reduced pruritus; three patients (15%) did not get any success with the medication; and three (15%) had the treatment interrupted due to side effects. CONCLUSION: In this study it can be concluded that dapsone is a safe and efficient option for patients presenting severe chronic urticaria non-responsive to antihistamines.
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    Dermatose por IgA linear induzida pela gestação
    (Soc Brasileira Dermatologia, 2008-01-01) Kanagusuko, Telma; Aoki, Valeria; Tebcherani, Antonio Jose [UNIFESP]; Galli Sanchez, Ana Paula; Complexo Hosp Padre Bento Guarulhos; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)
    Linear IgA disease is a rare autoimmune subepidermal bullous disorder characterized by linear IgA deposits at the epidermal basement membrane zone. According to the literature, in patients who have linear IgA disease and become pregnant, the disease tends to improve. We report a case of linear IgA disease induced by pregnancy, successfully treated with dapsone and prednisone with no adverse effects observed in the patient and her newborns.
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    Pioderma gangrenoso bolhoso e síndrome mielodisplásica
    (Sociedade Brasileira de Dermatologia, 2006-10-01) Batista, Mariana Dias [UNIFESP]; Fernandes, Ricardo Limongi [UNIFESP]; Rocha, Marco Alexandre Dias Da [UNIFESP]; Ikino, Juliana Kida [UNIFESP]; Pinheiro, Ronald Feitosa [UNIFESP]; Chauffaille, Maria de Lourdes Lopes Ferrari [UNIFESP]; Michalany, Nílceo Schwery [UNIFESP]; Almeida, Fernando Augusto De [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Pyoderma gangrenosum can present as a cutaneous manifestation of paraneoplastic syndromes. A case of bullous pyoderma gangrenosum associated with bicytopenia is described. During the complementary investigation, myelogram, bone marrow biopsy and karyotype were performed, and showed a pattern consistent with myelodysplastic syndrome. The patient was treated with dapsone with improvement. Pyoderma gangrenosum can be a manifestation of systemic diseases. The possibility of myelodysplastic syndrome should always be considered in patients with pyoderma gangrenosum associated with cytopenia. Pyoderma gangrenosum could indicate poorer prognosis in patients with systemic diseases.