Navegando por Palavras-chave "Cognitive enhancer"

Agora exibindo 1 - 1 de 1
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Modafinil Prevents Inhibitory Avoidance Memory Deficit Induced by Sleep Deprivation in Rats
    (Amer Acad Sleep Medicine, 2010-07-01) Moreira, Karin Monteiro [UNIFESP]; Ferreira, Tatiana Lima [UNIFESP]; Hipólide, Débora Cristina [UNIFESP]; Fomari, Raquel Vecchio [UNIFESP]; Tufik, Sergio [UNIFESP]; Menezes Oliveira, Maria Gabriela [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade Federal do ABC (UFABC); Univ Groningen, Univ Med Ctr Groningen
    Study Objectives: Evaluation of modafinil effects on the inhibitory avoidance task (IA).Design: Rats were trained on a multiple trial IA task after receiving modafinil or vehicle injections. In experiment 1 they were trained with a weak protocol under baseline condition and in experiment 2, with a stronger protocol under sleep-deprivation condition.Results: In experiment 1 modafinil improved rats' acquisition whereas the retention test remained unaffected. In Experiment 2 modafinil did not interfere with training performance, but the lower dose prevented the retention impairment in sleep-deprived animals.Conclusions: Modafinil is able to improve acquisition in normal rats and reverse the long-term memory impairment induced by sleep-deprivation.