Navegando por Palavras-chave "Clinical-Features"

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    Adaptive behavior in williams-beuren syndrome, down syndrome, and autism spectrum disorder
    (Revista De Saude Publica, 2016) Del Cole, Carolina Grego [UNIFESP]; Araripe, Beatriz L. [UNIFESP]; Silva, Ivaldo [UNIFESP]; Paula, Cristiane S.; Caetano, Sheila Cavalcante [UNIFESP]; Jackowski, Andrea Parolin [UNIFESP]
    Adaptive behavior (AB) is defined as the skills acquired in response to everyday life demands. AB profiles of genetic syndromes have been proposed, but the literature on them has not been conclusive, mainly due to the large number of these syndromes and marked within-profile variability. The aim of the present study was to analyze the different ABs observed in subjects with Williams-Beuren Syndrome (WBS), Down Syndrome (DS) and Autistic Spectrum Disorder (ASD) through a literature review using the PubMed and Scopus database. The results indicated that Socialization strongly affects WBS
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    Differential clinicopathological risk and prognosis of major papillary thyroid cancer variants
    (Oxford univ press inc, 2016) Shi, Xiaoguang; Liu, Rengyun; Basolo, Fulvio; Giannini, Riccardo; Shen, Xiaopei; Teng, Di; Guan, Haixia; Shan, Zhongyan; Teng, Weiping; Musholt, Thomas J.; Al-Kuraya, Khawla; Fugazzola, Laura; Colombo, Carla; Kebebew, Electron; Jarzab, Barbara; Czarniecka, Agnieszka; Bendlova, Bela; Sykorova, Vlasta; Sobrinho-Simoes, Manuel; Soares, Paula; Shong, Young Kee; Kim, Tae Yong; Cheng, Sonia; Asa, Sylvia L.; Viola, David; Elisei, Rossella; Yip, Linwah; Mian, Caterina; Vianello, Federica; Wang, Yangang; Zhao, Shihua; Oler, Gisele [UNIFESP]; Cerutti, Janete Maria [UNIFESP]; Puxeddu, Efisio; Qu, Shen; Wei, Qing; Xu, Huixiong; O'Neill, Christine J.; Sywak, Mark S.; Clifton-Bligh, Roderick; Lam, Alfred K.; Riesco-Eizaguirre, Garcilaso; Santisteban, Pilar; Yu, Hongyu; Tallini, Giovanni; Holt, Elizabeth H.; Vasko, Vasily; Xing, Mingzhao
    Context: Individualized management, incorporating papillary thyroid cancer (PTC) variant-specific risk, is conceivably a useful treatment strategy for PTC, which awaits comprehensive data demonstrating differential risks of PTC variants to support. Objective: This study sought to establish the differential clinicopathological risk of major PTC variants: conventional PTC (CPTC), follicular-variant PTC (FVPTC), and tall-cell PTC (TCPTC). Methods: This was a retrospective study of clinicopathological outcomes of 6282 PTC patients (4799 females and 1483 males) from 26 centers and The Cancer Genome Atlas in 14 countries with a median age of 44 years (interquartile range, 33-56 y) and median follow-up time of 37 months (interquartile range, 15-82 mo). Results: The cohort consisted of 4702 (74.8%) patients with CPTC, 1126 (17.9%) with FVPTC, and 239 (3.8%) with TCPTC. The prevalence of high-risk parameters was significantly different among the three variants, including extrathyroidal invasion, lymph node metastasis, stages III/IV, disease recurrence, mortality, and the use (need) of radioiodine treatment (all P < .001), being highest in TCPTC, lowest in FVPTC, and intermediate in CPTC, following an order of TCPTC > CPTC >> FVPTC. Recurrence and mortality in TCPTC, CPTC, and FVPTC were 27.3 and 6.7%, 16.1 and 2.5%, and 9.1 and 0.6%, corresponding to events per 1000 person-years (95% confidence interval [CI]) of 92.47 (64.66-132.26) and 24.61 (12.31-49.21), 34.46 (30.71-38.66), and 5.87 (4.37-7.88), and 24.73 (18.34-33.35) and 1.68 (0.54-5.21), respectively. Mortality hazard ratios of CPTC and TCPTC over FVPTC were 3.44 (95% CI, 1.07-11.11) and 14.96 (95% CI, 3.93-56.89), respectively. Kaplan-Meier survival analyses showed the best prognosis in FVPTC, worst in TCPTC, and intermediate in CPTC in disease recurrence-free probability and disease-specific patient survival. This was particularly the case in patients at least 45 years old. Conclusion: This large multicenter study demonstrates differential prognostic risks of the three major PTC variants and establishes a unique risk order of TCPTC > CPTC >> FVPTC, providing important clinical implications for specific variant-based management of PTC.