Navegando por Palavras-chave "Choroid diseases"

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    Estudo de toxicidade retiniana após injeções intravítreas seriadas de infliximabe em olhos de coelhos
    (Conselho Brasileiro de Oftalmologia, 2011-10-01) Rassi, Alan Ricardo; Rigueiro, Moacyr Pezati [UNIFESP]; Isaac, David Leonardo Cruvinel; Dourado, Letícia [UNIFESP]; Abud, Murilo Batista; Freitas, Éricka Campos; Carneiro, Luciana Barbosa; Ávila, Marcos Pereira de; Universidade Federal de Goiás Centro de Referência em Oftalmologia Ophthalmology Department; Universidade Federal de São Paulo (UNIFESP); Universidade Federal de Goiás Centro de Referência em Oftalmologia Setor de Retina e Vítreo; Universidade Federal de Goiás Centro de Referência em Oftalmologia Setor de Eletrofisiologia
    PURPOSE: To determine retinal and choroid toxicity levels of two and three infliximab intravitreous injections in albino rabbits by means of electroretinographic, histological and ophthalmological clinical tests. METHODS: 12 albino rabbits were used in the study. Each eye was given two (n=10 eyes) or three (n=10 eyes) serial intravitreous 2 mg infliximab injections dissolved in 0.06 ml of saline, at monthly intervals. A separate group of rabbits (n=4 eyes) served as a control group. Ninety days after the study had begun, the rabbits underwent clinical and electroretinographic tests, and after being enucleated, the eyes were examined for histological changes. RESULTS: Slit-lamp biomicroscopy and fundoscopic examination did not reveal any significant retinal abnormalities in the eyes injected with infliximab and control eyes or in pre- and post-treated eyes. The histological change that was noted was the presence of rare lymphocytes and eosinophils in the posterior vitreous of some of the rabbits subjected to two or three injections, but it was not considered clinically significant. A severe inflammatory reaction with vitreous exudates and ganglion cell edema in a single rabbit was clinically significant. The electroretinographic tests showed amplitudes that were on the average 12-13% smaller than those obtained before the treatment, however, there were no statistically significant differences when comparing the amplitude or the implicit time between pre- and post-treatment electroretinographic findings. CONCLUSION: Two and three intravitreous 2 mg infliximab injections in rabbits at monthly intervals did not cause any changes after a 90-day follow-up, according to histological and electroretinographic tests and after clinical evaluation. Differently from prior studies that have investigated potential retinotoxicity effects after single administrations, this study investigated the possibility of retinotoxicity after multiple injections. Clinical studies in humans should be conducted to better evaluate the safety of this drug in the treatment of certain diseases affecting the retina and the choroid.
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    Mudanças oculares durante a gestação
    (Conselho Brasileiro de Oftalmologia, 2009-04-01) Gouveia, Enéias Bezerra; Conceição, Paulo Sergio Pereira; Morales, Maira Saad de Avila [UNIFESP]; Hospital São Joaquim da Real e Benemérita Sociedade Portuguesa de Beneficência Serviço de Oftalmologia; Universidade São Paulo Faculdade de Medicina Serviço de Ginecologia-Obstetricia; Universidade Federal de São Paulo (UNIFESP)
    Pregnancy can cause several alterations in human eye function in healthy condition as well in ocular disease; these effects on the eyes are divided into three categories: physiologic alterations, ocular diseases changes already existing before the pregnancy, and pathological alterations. The present text proposes a bibliographical revision on the theme. The authors researched PubMed (MEDLINE) and LILACS databases.
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    Vasculopatia polipoidal idiopática da coróide
    (Conselho Brasileiro de Oftalmologia, 2002-06-01) Andrade, Rafael Ernane [UNIFESP]; Branco, André Castelo [UNIFESP]; Costa, Rogerio Alves [UNIFESP]; Uno, Fausto [UNIFESP]; Nakanami, Maurício [UNIFESP]; Guia, Tércio [UNIFESP]; Farah, Michel Eid [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Purpose: To describe the role of the optical coherence tomography, fluorescein and indocyanine green angiography findings in the diagnosis of idiopathic polypoidal choroidal vasculopathy (IPCV). Methods: A series of four eyes of three patients thought to have IPCV were examined and evaluated by optical coherence tomography, fluorescein and indocyanine green angiographies. Results: Fluorescein angiography was highly important for the diagnosis only in case 1. Indocyanine green angiography showed a branching network of the vessels with marginal vascular dilatations in all cases. Optical coherence tomography showed hemorrhagic detachment of the retinal pigment epithelium contiguous with the anterior delimitation of the polypoidal elements in two cases. Conclusion: The association of clinical manifestations with fluorescein and indocyanine green angiographies and optical coherence tomography can be useful in the differential diagnosis of exudative maculopathies, particularly IPCV with serohemorrhagic manifestations.