Navegando por Palavras-chave "Cebus apella"

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    Estudo morfológico do hipocampo de uma espécie de primata da Amazônia: Cebus apella, (Linnaeus, 1758)
    (Universidade Federal de São Paulo (UNIFESP), 2010-11-24) Torres, Laila Brito [UNIFESP]; Cavalheiro, Esper Abrão [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    The nonhuman primates constitute irreplaceable animal models for research areas in which their close evolutionary relationship to humans ensures high fidelity models with predictive and discriminative abilities that may not be available in other species. The Cebus apella, a New World primate specie belonging to the Cebidae family, Cebinae suborder (Linnaeus, 1758) are commonly used in biomedical and behavior research being the specie of choice for many cognitive experimental tasks. The hippocampus, a highly plastic limbic structure situated in the temporal lobe is important for learning and memory consolidation. In this way, the aim of this study was to characterize quantitatively and qualitatively the Parvalbumin positive cells in the hippocampal formation of the Cebus monkey and also estimate the volume and neuronal number in their different subfields using an optical fractionator design method. The results obtained in our study will be useful for many experimental designs in translational medicine.
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    Lymphocyte proliferation stimulated by activated Cebus apella macrophages treated with a complex homeopathic immune response modifiers
    (Elsevier B.V., 2012-01-01) Coelho Moreira, Carlos Onete; Ferreira Borges da Costa, Joana de Fatima; Leal, Mariana Ferreira [UNIFESP]; Andrade, Edilson Ferreira de; Rezende, Alexandre Pingarilho; Imbeloni, Aline Amaral; Pereira Carneiro Muniz, Jose Augusto; Cardoso Smith, Marilia de Arruda [UNIFESP]; Burbano, Rommel Rodriguez; Assumpcao, Paulo Pimentel de; Universidade Federal de São Paulo (UNIFESP); Fed Univ Para; Minist Saude
    Introduction: Canova is a complex homeopathic medicine that enhances a specific immunologic responses against several exogenous and endogenous conditions. Canova activates macrophages both in vivo and in vitro.Aim and method: We evaluated the effects of macrophages activated by Canova in vivo and ex vitro in the proliferation of lymphocytes. Canova was used to activate Cebus apella macrophages in vivo or ex vitro with Canova. Lymphocytes were cultured with the macrophage culture medium. the analysis of Canova effects in cultured lymphocytes was performed according to the cell cycle phase using flow cytometry. the Interferon gamma and Interleukin-5 cytokines quantification in these lymphocyte culture media was performed by Enzyme-linked immunosorbent assay (ELISA).Results: We observed that Canova actives macrophages in vivo and ex vitro. the lymphocytes cultured in a supplemented medium with macrophages activated by Canova treatment presented a higher number of proliferation cells than lymphocytes not exposed to macrophages activated by Canova. the Interferon gamma and Interleukin-5 cytokines were only observed in the medium of lymphocytes exposed to macrophages activated by Canova. Thus, Canova has potential as a new adjuvant therapy. Homeopathy (201 2) 101, 74-79.
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    The protective effect of Canova homeopathic medicine in cyclophosphamide-treated non-human primates
    (Elsevier B.V., 2012-12-01) Leal, Mariana Ferreira [UNIFESP]; Antunes, Lusania Maria Greggi; Lamarao, Maria Fernanda Vita; Silva, Carla Elvira Araujo da; Silva, Ismael Dale Cotrim Guerreiro da [UNIFESP]; Assumpcao, Paulo Pimentel; Andrade, Edilson Ferreira; Rezende, Alexandre Pingarilho; Imbeloni, Aline Amaral; Muniz, Jose Augusto Pereira Carneiro; Pinto, Giovanny Reboucas; Smith, Marilia de Arruda Cardoso [UNIFESP]; Burbano, Rommel Rodríguez [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP); Fed Univ Para; Minist Saude; Univ Fed Piaui
    Background: Canova activates macrophages and indirectly induces lymphocyte proliferation. Here we evaluated the effects of Canova in cyclophosphamide-treated non-human primates.Methods: Twelve Cebus apella were evaluated. Four animals were treated with Canova only. Eight animals were treated with two doses of cyclophosphamide (50 mg/kg) and four of these animals received Canova. Body weight, biochemistry and hematologic analyses were performed for 40 days. Micronucleus and comet assays were performed for the evaluation of DNA damage.Results: We observed that cyclophosphamide induced abnormal WBC count in all animals. However, the group treated with cyclophosphamide plus Canova presented a higher leukocyte count than that which received only cyclophosphamide. Cyclophosphamide induced micronucleus and DNA damage in all animals. the frequency of these alterations was significantly lower in the Canova group than in the group without this medicine.Conclusions: Our results demonstrated that Canova treatment minimizes cyclophosphamide myelotoxicity in C. apella. (C) 2012 Elsevier B.V. All rights reserved.
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    Three-dimensional Characteristics of the Interface Epithelium-Connective Tissue Surface of Finger's Lamina Propria of Cebus apella Monkey: Scanning Electron Microscopy Study
    (Soc Chilena Anatomia, 2008-06-01) Watanabe, Ii-Sei [UNIFESP]; Guimaraes, Juliana Placido; Iyomasa, Mamie Misuzaki; Miglino, Maria Angelica; Lopes, Marilia Gabriela de Oliveira; Consentino, Marcia; Sosthines, Kronka; Pereira da Silva, Marcelo Cavenaghi [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Fed Univ Belem; Univ Vale Paraiba; Universidade de São Paulo (USP)
    In the present paper were analysed the three-dimensional characteristics of the interface epithelium-connective tissue surface of finger prints of Cebus apella monkey employing the scanning electron microscopic methods. The connective tissue core (CTC) and epithelial papillae were examined verifying the three-dimensional configuration of the tissue projections. The samples were fixed in Bouin solsution for histologic preparations and in modified Karnovsky for examine to observe in scanning electron microscopy. After treatment in the 10% NaOH solution during 3 to 5 days, the surface of finger prints revealed a distribution of CTC of lamina propria in situ showing original three-dimensional SEM images. The linear and circular dispositions CTC, and the furrows were clearly identified. Each pointed papilla presented a large base and longitudinal disposition of thick collagen fiber bundles and in some areas with a complex reticular formations. The longitudinal furrows between the pointed papillae exhibited a dense layer of connective tissue and showed only low CTC or laminar in shape. The presence of numerous foramina of sweat gland were noted in three-dimensional SEM images.