Navegando por Palavras-chave "Caries"

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    Avaliação das dificuldades alimentares e mastigatórias e sinais e sintomas de bruxismo em crianças com Síndrome de Down
    (Universidade Federal de São Paulo, 2023-05-02) Miyagui, Sânia Aparecida [UNIFESP]; Castelo, Paula Midori [UNIFESP]; Fernandes, Mariana dos Santos; http://lattes.cnpq.br/4525318283387445
    Down Syndrome is a condition associated to particular and specific characteristics regarding oral health and growth of orofacial structures that can directly affect dietary, nutritional and masticatory aspects. The objective of the study was to evaluate the oral and nutritional clinical characteristics, feeding and masticatory difficulties, as well as signs and symptoms of bruxism in 100 individuals with Down Syndrome aged between five and 18 years (median=12 years). According to the medical history, 59% of the participants did not have chronic diseases, while 14% had thyroid gland dysfunction and 17% had cardiovascular diseases. Delays in the chronology of eruption of permanent teeth were observed, in addition to a higher frequency of Class III molar relationship in the permanent dentition. The mean index of decayed, missing (or exfoliated) and filled teeth (dmf/DMFT) was higher according to the stage of dentition, being equal to 1.1 in the deciduous dentition and 2.5 in the permanent dentition; at 14-18 years old caries experience was 82%. Frequencies of bleeding on inspection and periodontal pockets were found in 26.5% and 10% of participants in the mixed dentition, and 77% and 45.5% in the permanent dentition, respectively. The frequencies of visible biofilm and reported teeth grinding/clenching were found to be 97-100% and 70-82% in the three dentitions. As for nutritional and dietary aspects, the frequency of children with excess weight (overweight, preobesity and obesity) increased according to age, being 39% in the age range of 5-7 years and 54% in the range of 14-18 years; 30% of the participants did not receive natural breastfeeding and the average time of bottle feeding was 29.7 months. The consumption of fresh fruit had a median=5 (every day) in all age groups, although the intake of juices, soft drinks and sausages was high and the consumption of sweets and biscuits increased with age. According to parents, most participants were classified as having no feeding difficulties (87%) and only eight children were classified as having moderate to severe difficulties. Masticatory difficulties were more frequent in the age group of 8-10 years, corresponding to the mixed dentition. Comparing with literature data obtained in typical children, delays in tooth eruption, higher frequency of Molar Class III, high levels of visible biofilm and teeth grinding or clenching were observed in children and adolescents with Down Syndrome. Furthermore, the high consumption of sweets and processed foods, the longer duration of bottle feeding and the frequency of overweight observed indicate the high risk of caries, cardiovascular and metabolic diseases to which this population is exposed.
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    Estudo da freqüência de cárie e fatores associados no diabetes mellitus tipo 1
    (Sociedade Brasileira de Endocrinologia e Metabologia, 2006-06-01) Amaral, Fábio Menasce Franco do [UNIFESP]; Ramos, Patrícia G. De A.; Ferreira, Sandra Roberta Gouvea [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)
    Subjects with diabetes mellitus (DM) are more prone to certain disturbances of oral cavity but there are controversies concerning caries. This cross-sectional study investigated the frequency of caries and associated factors, in a sample of population with or without type 1 DM, including non-diabetic (53 women, 31 men) and 30 diabetic subjects (19 women, 11 men) aged 17-28 years. Diagnosis of dental caries was based on the DMF-T index (D= decay; M= miss; F= fill; T= teeth); in addition, a plaque control record (PCR) was obtained. A preponderance of female sex was found within the groups studied but such proportions did not differ when comparing diabetic and non-diabetic groups. Mean ages were 21.0 ± 2.2 and 19.5 ± 1.8 years, respectively for subjects without and with DM (p< 0.05). Education level was higher in the non-diabetic group as well as the DMF-T index (10.5 ± 5.8 vs. 6.7 ± 5.7, p< 0.01). Linear regression analysis (n= 114) showed significant associations of DMF-T with age, sucrose intake, daily frequency of tooth brushing, of dental floss use, PCR and of visits to the dentist. By ANOVA model with age as a covariate the non-diabetic condition (p= 0.047), sucrose index and PCR (r²= 0.820) were independently associated with the DMF-T. In the diabetic-specific model, with only the diabetic subjects included and sucrose index as a covariate, DM duration, fundus abnormality and PCR were significantly associated with the presence of caries (r²= 0.816). The sample of type 1 diabetic subjects suggest that they are less prone to caries than non-diabetics, despite having a higher frequency of meals, less tooth brushing and dental floss use. We speculate that DM duration may contribute to the occurrence of caries and restricted sucrose consumption to lower frequency of caries in diabetic subjects.
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    Frequência Dos Defeitos Do Desenvolvimento Do Esmalte E Cárie Em Dentes Permanentes De Adolescentes Nascidos Pré Termo E Termo
    (Universidade Federal de São Paulo (UNIFESP), 2018-05-04) Alves, Stella Maria Coda Pinto [UNIFESP]; Kopelman, Benjamin Israel [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Introduction: The Enamel Developmental Defects On Permanent Dentition Have A Negative Impact On Oral Health, Esthetics And Tooth Sensitivity. Objective: To Evaluate Frequency And Distribution Of Enamel Developmental Defects (Dde), Hypomineralization Molar Incisor (Hmi) And Carie Experience (Dmft) In Permanent Teeth Of Adolescents Pre Term And Term. To Evaluate The Association Between Dde, Hmi And Pos Natal And Peri Natal Morbidity In Adolescents Born Pre Term And Term. Methods: Cross Sectional Study Was Conducted With 255 Adolescents (10 -19 Years) Followed Up By Two Ambulatories Services Of Federal University Of São Paul, Brazil. Dde And Mih Was Described Using Dde Index And European Academy Of Paediatric Dentistry (Eapd) Criteria. The Carie Experience Was Analysed Using Dmft Index. Results And Conclusions: 141 (55,7%) Of The Subject Were Born Pre Term And 114 (44,7%) Were Born Term. Prematury Was Associated With Dde And Hmi. Overwall Available Adolescents, There Were 29% With Low Probability, 38% With Mediu
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    Oral microbial colonization in children with sickle cell anaemia under long-term prophylaxis with penicillin
    (Elsevier B.V., 2014-10-01) Matos, Bruno Mello de; Abreu Ribeiro, Zulene Eveline; Balducci, Ivan; Figueiredo, Maria Stella [UNIFESP]; Back-Brito, Graziella Nuernberg; Mota, Adolfo Jose da; Pellegrini Braga, Josefina Aparecida; Koga-Ito, Cristiane Yumi; Univ Estadual Paulista; Universidade Federal de São Paulo (UNIFESP); Univ Fed Amazonas
    Background and objective: Sickle cell anaemia (SCA) is the most frequent haematological hereditary disease. Children with SCA are submitted to long-term prophylactic therapy with penicillin, but little is known about its impact on oral microflora. the aim of this study was to evaluate the oral microbial colonization of paediatric patients with SCA.Design: Forty children (4-11 yrs old) with SCA (genotype SS) under long-term prophylactic treatment with penicillin were included in the study. Age/gender-matched control group of healthy children was also included. Scores of dmft/DMFT (number of decayed (D), missing (M), or filled (F) teeth; dmft, for primary dentition; DMFT, for permanent dentition) were obtained and stimulated saliva was sampled. Salivary flow rate and buffering capacity were evaluated. Counts of microorganisms (mutans streptococci, lactobacilli and yeasts) were determined by plating method. Yeasts were identified by API 20C AUX and PCR.Results: Mean dmft/DMFT values were similar in the studied groups (SCA 2.13/1.60 and control 2.38/1.3). Although no significant differences between cariogenic microorganism counts were observed, significantly higher yeasts oral levels were observed in SCA group. Controls showed lower salivary buffering capacity. Candida albicans was the most frequently isolated species in both groups. Candida famata, Candida parapsilosis and Candida tropical is were also isolated from controls. Candida dubliniensis, Candida rugosa and Candida sphaerica were found only in SCA group.Conclusions: Based on the results, it could be concluded that paediatric patients with SCA showed significantly higher oral level of yeasts. Uncommon fungal species were found in SCA group. Similar caries prevalence and counts of lactobacilli and streptococci in relation to controls were observed. (C) 2014 Elsevier B.V. All rights reserved.
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    Resposta dos odontoblastos aos receptores ativados por protease e aos cimentos resinosos autoadesivos na mineralização da matriz dentinária
    (Universidade Federal de São Paulo, 2021-06-15) Alvarez, Marcela [UNIFESP]; Tersariol, Ivarne [UNIFESP]; Nacimento, Fábio [UNIFESP]; http://lattes.cnpq.br/6593247187880200; http://lattes.cnpq.br/4859954582615304; http://lattes.cnpq.br/0175345882910812; Universidade Federal de São Paulo - UNIFESP
    INTRODUÇÃO. Os odontoblastos estão localizados no complexo pulpo-dentinário e são responsáveis pela síntese da matriz dentinária. Por estarem estrategicamente localizados na interface da polpa com a dentina, são responsáveis pela sinapse imunológica da matriz dentinária com a polpa. O objetivo principal desta tese foi estudar a presença e a resposta biológica das células odontoblasto-like (MDPC-23) e das células-tronco pulpar humana (DPSCs) aos receptores ativados por protease PAR-1 e PAR-2, ambos reconhecidos por regular processos inflamatórios no processo de mineralização da matriz. Também estudamos a resposta biológica das células MDPC-23 à presença de cimentos resinosos autoadesivos, MaxCem Elite e RelyXU200. MATERIAIS E MÉTODOS. Os receptores PAR-1 e PAR-2 nas células MDPC-23 foram caracterizadas por de ensaios de qRT-PCR, citometria de fluxo, western blot e microscopia confocal. A funcionalidade de dos receptores PAR-1 e PAR-2 foi analisada por ensaios farmacológicos medindo o infuxo citoplasmático de cálcio em resposta aos agonistas dos receptores. Após a indução por LPS analisamos por qRT-PCR a expressão dos receptores PAR-1 e PAR-2, bem como, de citocinas inflamatórias. Também, verificamos a presença e a funcionalidade dos receptores PAR nas células-tronco da polpa dentária (DPSC). Bem como, estudamos o impacto dos cimentos resinosos no estresse oxidativo celular, na proliferação celular e na capacidade de indução de mineralização da matriz. RESULTADOS E DISCUSSÃO. Os resultados mostram que as células MDPC-23 expressam constitutivamente PAR- 1 e PAR-2. O peptídeo agonista de PAR-1 foi capaz de fosforilar ERK, e a ativação de PAR-2 promoveu infuxo citoplasmático de cálcio. Na presença de LPS, houve aumento na expressão gênica dos receptores PAR-1 e PAR-2 e das citocinas inflamatórias TNF-α e IL-6. Houve alteração na expressão gênica de metaloproteases (MMPs) mediado pelos peptídeos agonistas de PAR-1 e PAR-2. Por análises de espectrometria de massa verificamos o aumento da presença de MMP-13 capaz de hidrolisar o peptídeo-FRET mimético de PAR-1 no sítio não canônico TLDPRS42↓F43LL, bem como, de serino proteases da família de tripsina capaz de clivar o peptídeo-FRET mimético de PAR-2 no sítio canônico SKGR20↓S21LIGRL no extrato pulpar acometido por pulpite em relação ao extrato pulpar de dentes não inflamados, esses resultados suportam a hipótese da ativação de PAR-1 e PAR-2 por proteases endógenas do dente, abundantes durante a resposta inflamatória no complexo pulpo-dentinário. Cortes histológicos de tecido dentário cariado mostrou intensa coloração positiva de PAR-1 e PAR-2 nos processos de odontoblastos em relação ao dente não-cariado. Ainda, PAR-1 foi capaz de aumentar a expressão, atividade e potencial mineralizador das células MDPC-23. PAR-2 não promoveu aumento na atividade da fosfatase alcalina, assim como não houve aumento de depósitos de minerais. Nas DPSCs, verificamos a expressão de PAR-1 e PAR-2 e, na presença de agonista de PAR-1, verificamos aumento na expressão de genes importantes envolvidos no processo de diferenciação/ mineralização, assim como houve aumento na produção de cristais de hidroxiapatita. Ainda, houve aumento na expressão de interleucinas inflamatórias importantes na presença de PAR-1 ou PAR- 2. Em relação aos cimentos resinosos autoadesivos, verificamos diferentes graus de citotoxicidade para as células MDPC-23 em função do tipo de cimento. Bem como, encontramos alterações na expressão de RNAm de genes pró-inflamatórios, genes envolvidos na mineralização e no estresse oxidativo das células MDPC-23. As alterações na expressão dos genes foram acompanhadas pela monitoração das alterações fenotípicas observadas sobre a proliferação celular, produção de espécies reativas de oxigênio e capacidade de mineralização da matriz na presença dos cimentos. CONCLUSÃO. Os resultados apresentados demonstraram que os receptores PARs estão envolvidos na resposta inflamatória e no remodelamento da matriz dentinária, PAR-1 possui papel na indução de mineralização da matriz e na diferenciação das células-tronco pulpares. Ainda, PAR-2 parece modular a resposta do receptor nociceptivo TRPV1 em odontoblastos, através de mecanismos ainda a serem elucidados. Também observamos que ambos os cimentos resinosos autoadesivos atuam de forma distinta ao modular a resposta redox nas células MDPC-23, alterar a proliferação celular e capacidade mineralização destas células. Esses resultados obtidos servem para balizar a produção de cimentos odontológicos mais biocompatíveis com o tecido dentário.
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    Severity of malocclusion in adolescents: populational-based study in the north of minas gerais, brazil
    (Wiley-Blackwell, 2016) Silveira, Marise Fagundes; Freire, Rafael Silveira; Nepomuceno, Marcela Oliveira; de Barros Lima Martins, Andrea Maria Eleuterio; Marcopito, Luiz Francisco [UNIFESP]
    OBJECTIVE: To identify the factors associated with severity of malocclusion in a population of adolescents. METHODS: In this cross-sectional population-based study, the sample size (n = 761) was calculated considering a prevalence of malocclusion of 50.0%, with a 95% confidence level and a 5.0% precision level. The study adopted correction for the effect of delineation (deff = 2), and a 20.0% increase to offset losses and refusals. Multistage probability cluster sampling was adopted. Trained and calibrated professionals performed the intraoral examinations and interviews in households. The dependent variable (severity of malocclusion) was assessed using the Dental Aesthetic Index (DAI). The independent variables were grouped into five blocks: demographic characteristics, socioeconomic condition, use of dental services, health-related behavior and oral health subjective conditions. The ordinal logistic regression model was used to identify the factors associated with severity of malocclusion. RESULTS: We interviewed and examined 736 adolescents (91.5% response rate), 69.9% of whom showed no abnormalities or slight malocclusion. Defined malocclusion was observed in 17.8% of the adolescents, being severe or very severe in 12.6%, with pressing or essential need of orthodontic treatment. The probabilities of greater severity of malocclusion were higher among adolescents who self-reported as black, indigenous, pardo or yellow, with lower per capita income, having harmful oral habits, negative perception of their appearance and perception of social relationship affected by oral health. CONCLUSIONS: Severe or very severe malocclusion was more prevalent among socially disadvantaged adolescents, with reported harmful habits and perception of compromised esthetics and social relationships. Given that malocclusion can interfere with the self-esteem of adolescents, it is essential to improve public policy for the inclusion of orthodontic treatment among health care provided to this segment of the population, particularly among those of lower socioeconomic status.