Navegando por Palavras-chave "Brain neoplasms"
Agora exibindo 1 - 7 de 7
Resultados por página
Opções de Ordenação
- ItemSomente MetadadadosA data mining system for providing analytical information on brain tumors to public health decision makers(Elsevier B.V., 2013-03-01) Santos, R. S.; Malheiros, S. M. F. [UNIFESP]; Cavalheiro, S. [UNIFESP]; Parente de Oliveira, J. M.; Aeronaut Inst Technol; Universidade Federal de São Paulo (UNIFESP); Compuminer Data Min & BICancer is the leading cause of death in economically developed countries and the second leading cause of death in developing countries. Malignant brain neoplasms are among the most devastating and incurable forms of cancer, and their treatment may be excessively complex and costly. Public health decision makers require significant amounts of analytical information to manage public treatment programs for these patients. Data mining, a technology that is used to produce analytically useful information, has been employed successfully with medical data. However, the large-scale adoption of this technique has been limited thus far because it is difficult to use, especially for non-expert users. One way to facilitate data mining by non-expert users is to automate the process. Our aim is to present an automated data mining system that allows public health decision makers to access analytical information regarding brain tumors. the emphasis in this study is the use of ontology in an automated data mining process. the non-experts who tried the system obtained useful information about the treatment of brain tumors. These results suggest that future work should be conducted in this area. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
- ItemAcesso aberto (Open Access)Disfagia após ressecção de tumor de fossa posterior em pacientes pediátricos: queixa, incidência, caracterização e fatores de risco(Universidade Federal de São Paulo (UNIFESP), 2017-02-24) Correa, Cláudia Carolina da Silva [UNIFESP]; Goncalves, Maria Ines Rebelo [UNIFESP]; Honsi, Nathalia Oliveira Bortolatto; http://lattes.cnpq.br/0516074277172162; http://lattes.cnpq.br/9327083927146744; Universidade Federal de São Paulo (UNIFESP)Objetivos: Verificar as incidências de queixa de deglutição e de disfagia, caracterizar o grau de gravidade da disfagia e identificar fatores de risco para a disfagia em casos de ressecção de tumor fossa posterior na população pediátrica. Métodos: Foram analisados prontuários médicos e fonoaudiológicos de pacientes pediátricos submetidos à ressecção de tumor de fossa posterior no Instituto de Oncologia Pediátrica – Grupo de Apoio ao Adolescente e à Criança com Câncer (IOP-GRAACC/Unifesp). Os pacientes foram classificados quanto à presença ou ausência de queixa de deglutição referida no pós-operatório. Em seguida, independente da presença ou ausência de queixa, foram classificados como deglutição normal ou disfágicos; foram considerados disfágicos quando, no registro médico e/ou fonoaudiológico, houve presença de disfagia com avaliação clínica e/ou objetiva da deglutição. O grau de gravidade da disfagia foi estabelecido pela escala DOSS e foram levantados dados do pós-operatório para associar a disfagia com possíveis fatores de risco. Resultados: 120 ressecções de tumor de fossa posterior foram levantadas em 100 prontuários de pacientes. A amostra foi caracterizada por indivíduos do sexo feminino (36%) e do sexo masculino (64%), com idade entre 8 meses e 16 anos e 8 meses, média de 7 anos. A maioria das queixas relacionadas à deglutição foram apresentadas por pacientes com disfagia, mas indivíduos com deglutição normal também a referiram; houve necessidade de via alternativa de alimentação em 34,2% dos pós-operatórios, sendo que destes 77,1% apresentavam distúrbio de deglutição. Dos pacientes disfágicos, mais da metade evoluiu com disfagia de grau grave. Dentre os fatores de risco estudados verificamos que os indivíduos com distúrbio de deglutição apresentaram: mediana de idade menor, média de tempo de intubação orotraqueal de 3,94 dias, necessidade de suporte ventilatório após desintubação e, evoluíram com acometimento de pares cranianos associados ou isolados (77,1%), paralisia facial (66,7%) e alteração vocal (62,5%). Conclusões: A incidência de queixa de deglutição foi de 13,3%, seguida de uma incidência de 40% de disfagia; o distúrbio de deglutição foi caracterizado como de grau grave na maioria dos pacientes; foram considerados fatores de risco: crianças com idade menor, maior tempo de intubação orotraqueal, ressecção cirúrgica parcial, localização tumoral em IV ventrículo e tronco cerebral, presença de disartria, acometimento de pares cranianos associados ou isolados, utilização de suporte ventilatório e acometimento motor.
- ItemSomente MetadadadosEsclerose tuberosa: aspectos atuais e associação a tumores cerebrais(Universidade Federal de São Paulo (UNIFESP), 1991) Zymberg, Samuel Tau [UNIFESP]; Tella Júnior, Oswaldo Inácio de [UNIFESP]
- ItemAcesso aberto (Open Access)Estudo epidemiológico de pacientes pediátricos portadores de tumor do sistema nervoso central matriculados no Instituto de Oncologia Pediátrica(Universidade Federal de São Paulo (UNIFESP), 2010-09-29) Pinho, Ricardo Silva [UNIFESP]; Vilanova, Luiz Celso Pereira [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Purpose: Central nervous system (CNS) tumors comprise the most frequent group of solid malignant tumors in pediatric patients, representing approximately 20% of all tumors in children under the age of 15. The objective of this study was to determine the epidemiology of primary tumors of the CNS in pediatric patients from a Brazilian oncology institute. Methods: We retrospectively analyzed 741 charts (415 males and 326 females) from patients under 21 years of age who were diagnosed with a CNS tumor. The analysis included patients from 1989 to 2009 and was completed using the World Health Organization criteria. We evaluated the distribution of age, gender, topography, clinical symptoms, symptom intervals and classification of the tumors. Patients with clinical/radiological diagnoses were included. Results: Seven hundred and forty-one patients with tumors in the CNS were reviewed, and 75% of the patients presented a histological diagnosis. Males (56%) were more prevalent than females. In children under the age of three, the supratentorial compartment was the predominant region involved (51,3%). Astrocytoma was the most frequent tumor type (39,9%), followed by medulloblastoma (14,0%), craniopharyngioma (10,4%) and ependymoma (6,9%). Headaches were the most common symptom, and the symptom intervals varied from 1 to 5.010 days. Approximately 4% of the patients had associated genetic syndromes. Conclusions: The authors analyzed a group of pediatric patients with CNS tumors in a Brazilian referral hospital. Although this was not a population study and selection bias may have occurred, our data may be representative of the Brazilian population.
- ItemAcesso aberto (Open Access)Functional Assessment of Cancer Therapy-Brain questionnaire: translation and linguistic adaptation to Brazilian Portuguese(Associação Paulista de Medicina - APM, 2011-01-01) Gazzotti, Mariana Rodrigues [UNIFESP]; Alith, Marcela Batan; Malheiros, Suzana Maria Fleury [UNIFESP]; Vidotto, Milena Carlos [UNIFESP]; Jardim, José Roberto [UNIFESP]; Nascimento, Oliver Augusto [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Lar Escola São FranciscoCONTEXT AND OBJECTIVE: Quality of life assessment among patients with brain tumors is important, given that new treatments have increased patient survival. The aim of this study was to translate the Functional Assessment of Cancer Therapy-Brain (FACT-Br) questionnaire (version 4) into Portuguese, carry out cross-cultural adaptation and assess its reproducibility. DESIGN AND SETTING: Cohort at the Universidade Federal de São Paulo (UNIFESP). METHODS: Forty patients with a brain tumor seen at the neuro-oncology outpatient clinic participated in the study. The process of translation and back-translation was carried out, along with adaptation to the Portuguese language and Brazilian culture. The intraclass correlation coefficient (ICC) was used to test the reproducibility of the FACT-Br (version 4). RESULTS: The reproducibility of the questionnaire was excellent (ICC = 0.95; 95% confidence interval, CI: 0.89-0.97). The ICC with a mean interval of 15 days between applications of the questionnaire was very good in all domains (ICC = 0.87 to 0.95). The mean time taken to answer the questionnaire was 6.27 ± 2.26 minutes, ranging from 3 to 11 minutes. CONCLUSION: The translated version of the FACT-Br questionnaire (version 4) adapted to the Portuguese language and Brazilian culture proved to be easily understood and achieved very good reproducibility among patients with diagnoses of brain tumors.
- ItemAcesso aberto (Open Access)Reabilitação fonoaudiológica da disfagia em pacientes pediátricos com tumor encefálico(Universidade Federal de São Paulo (UNIFESP), 2010-02-24) Radzinsky, Tatiana Couto [UNIFESP]; Gonçalves, Maria Inês Rebelo [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Objective: To verify the efficacy of the dysphagia therapy performed by speech pathologists in pediatric patients with brain tumors using the Functional Oral Intake Scale (FOIS; Crary et al, 2005). Materials and Methods: The sample consisted children and adolescents with central nervous system tumors (23 male and 8 female), ages ranging from 11 months to 22 years old. Was performed a retrospective charts review of patients with central nervous system tumors and diagnosed oropharyngeal dysphagia, that were submitted to swallowing rehabilitation during internment period at the Pediatric Oncology Institute (IOP/GRAACC/UNIFESP) in the period from September 2003 to July 2009. To obtain the data, an evolution chart protocol was created, comprising patient’s identification, gender, initial diagnosis, underlying disease, injury site, speech-language diagnosis, specific tumor treatment, speech-language evaluation date, speech-language discharge date, number of speech-language therapy sessions, complications during the therapy period, respiratory conditions, and intubation period. Was used the Functional Oral Intake Scale (FOIS), a functional feeding evaluation scale, enabling to classify the patient according to the feeding intake (Crary, 2005). In addition, for speech-language diagnosis definition, and modified version of the Dysphagia Outcome and Severity Scale (O’Neil, 1999) was utilized. The scores were registered during the pre therapy period (speech-language functional evaluation) and post therapy. Improvement was considered when there was a change in the score to level 5 or higher, and decline when the score changed level 5 or lower. Results: All 31 patients showed improvement in the FOIS scale level after speech-language therapy. Level 5 or higher was achieved by 17 (54.8%) and was observed that 14 patients (45.2%) maintained the same FOIS level, not evolving as adequately. Results show that 19 patients (61.7%) presented severe dysphagia during the pre therapy period, out of those 11 (57.9%) managed to evolve to mild dysphagia, functional deglutition or normal deglutition. The dysphagia severity degree lowered in the post therapy on 21 patients (67.7%) while 10 (32.3%) maintained the same score. Conclusion: The patients that showed major improvement on the FOIS level had few clinical complications, tumors with better prognosis, and mean age of 12 years, whereas the patients that evolved in a less significant manner all presented clinical complications (decreased level of alertness and/or worsening of the clinical picture), tumors with bad prognosis (glioblastoma multiform stage IV, anaplasic ependymoma stage II, high-grade meduloblastoma, and brainstem glioma), in addition to mean age of 7.8 years.
- ItemAcesso aberto (Open Access)Tumor growth analysis by magnetic resonance imaging of the C6 glioblastoma model with prospects for the assessment of magnetohyperthermia therapy(Instituto Israelita de Ensino e Pesquisa Albert Einstein, 2012-03-01) Silva, André César da; Cabral, Francisco Romero [UNIFESP]; Mamani, Javier Bustamante; Malheiros, Jackeline Moraes [UNIFESP]; Polli, Roberson Saraiva [UNIFESP]; Tannus, Alberto; Vidoto, Edson; Martins, Mateus José; Sibov, Tatiana Tais; Pavon, Lorena Favaro; Miyaki, Liza Aya Mabuchi; Cárdenas, Walter Humberto Zavala; Malheiros, Suzana Maria Fleury [UNIFESP]; Brandt, Reynaldo André; Amaro Junior, Edson; Gamarra, Lionel Fernel; Hospital Israelita Albert Einstein Brain Institute; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP); Hospital Israelita Albert Einstein Department of Oncology; Sociedade Beneficente Israelita Brasileira Albert Einstein Neuro-Oncology CenterOBJECTIVE: The objective was to establish a pattern of tumor growth of the C6 model of glioblastoma multiform in Wistar rats via magnetic resonance imaging (MRI) for the subsequent verification of tumor volume reduction due to magnetic hyperthermia therapy. METHODS: Young male Wistar rats weighing between 250 and 300 g were used for the C6 model. After the rates were anesthetized (55 mg/kg ketamine and 11 mg/kg xylazine), C6 lineage tumorigenic cells suspended in culture medium (10(5) cells in 10 µl) were stereotaxically injected into the right frontal cortex (bregma coordinates: 2.0 mm anteroposterior, 3.0 mm laterolateral, and 2.5 mm depth) of the rats using a Hamilton syringe. For the control group, the rats were injected with culture medium without cells. MRI scans were performed at 14, 21, and 28 d after the injection using a 2.0 T MRI scanner (Bruker BioSpec, Germany). The animals were anesthetized with 55 mg/kg ketamine and 11 mg/kg xylazine before being examined. Coronal multilayers were acquired using a standard spin echo sequence with the following parameters: repetition/echo time = 4.000 ms/67.1 ms, field of view = 3.50, matrix = 192, slice thickness = 0.4 mm, and slice separation = 0 mm. RESULTS: The MRI analysis enabled a clear visualization of the tumor mass, and it was possible to establish the tumor volume parameters on the various days that were examined. The volume at 14 d after induction was 13.7 ± 2.5 mm³. On days 21 and 28, the tumor volumes were 31.7 ± 6.5 mm³ and 122.1 ± 11.8 mm³, respectively. CONCLUSION: These results demonstrated that it is possible to evaluate the C6 model tumor volume in rats, which will allow for the future implementation and verification of magnetic hyperthermia therapy.