Navegando por Palavras-chave "Banco De Dados"
Agora exibindo 1 - 4 de 4
Resultados por página
Opções de Ordenação
- ItemAcesso aberto (Open Access)Cirurgia de revascularização do miocárdio no Brasil: análise crítica da realidade nacional através do registro Bypass(Universidade Federal de São Paulo (UNIFESP), 2019-12-18) Paez, Rodrigo Pereira [UNIFESP]; Gomes, Walter Jose [UNIFESP]; Hossne Junior, Nelson Américo [UNIFESP]; http://lattes.cnpq.br/1049536043140541; http://lattes.cnpq.br/9877675594064089; http://lattes.cnpq.br/0562313854343144; Universidade Federal de São Paulo (UNIFESP)Introduction: Coronary artery bypass grafting (CABG) is the most frequently performed heart surgery in Brazil. Recent international guidelines recommend that national societies establish a registry database on surgical practice and results. Anticipating this recommendation, the BYPASS registry started in 2015. Objective: To analyze the profile, risk factors and outcomes of patients undergoing CABG in Brazil, as well as examine the predominant surgical strategy, based on the data included in the BYPASS Registry. Methods: This is a cross-sectional study of 2292 patients undergoing CABG and included in the BYPASS Registry up to November, 2018. Demographic data, clinical presentation, operative variables, and postoperative hospital outcomes were analyzed. Results: Patients referred to CABG in the Registry were predominantly male (71%), with previous myocardial infarction in 41.1% of cases, diabetes in 42.5%, and left ventricular ejection fraction lower than 40% in 9.7%. Surgery was indicated by Heart Team in 32.9% of the cases. Most of the patients underwent cardiopulmonary bypass (87%), where the use of cardioplegia was the strategy of myocardial protection chosen in 95.2% of the cases. The left internal thoracic artery (ITA) was used as graft in 91% of the cases; the right ATI, in 5.6%; and; the radial artery, in 1.1%. The saphenous vein graft was used in 84.1% of the patients, being the only graft employed in 7.7% of the patients. The median of coronary vessels treated was 3. Operative mortality was 2.8%, and the incidence of stroke was 1.2%. Conclusion: CABG data in Brazil provided by the BYPASS registry analysis is representative of our national reality and practice. This database constitutes an important reference for indications and comparisons of therapeutic procedures, as well as to propose subsequent models to improve patient safety and the quality of surgical practice in the country.
- ItemAcesso aberto (Open Access)Desenvolvimento de interface para coleta de dados em pesquisa clínica em Oftalmologia(Universidade Federal de São Paulo (UNIFESP), 2020-05-28) Ribeiro, Ivan Rogerio [UNIFESP]; Hirai, Flavio Eduardo [UNIFESP]; Universidade Federal de São PauloThe Information technology (IT) has a fundamental role in the health, in the fields of care, teaching and research. Clinical research should be widely disclosed and widespread in the academia, once it is one of the pillars in the training of health professionals. One of the difficulties encountered while conducting research is data collection. Objective: To develop a data collection platform for clinical research to facilitate and streamline statistical analysis. Method: The pertinent needs to this subject were detected with the professors involved in the graduate programs of the Department of Ophthalmology. Different possibilities were analyzed with the Information Technology (IT) team at the Federal University of São Paulo (Unifesp) and it was decided to develop a platform hosted within Unifesp existing environment. The platform was called “PAEOFTA” and the interfaces were compiled in the form of a “User Manual” to facilitate its use. Results: A test was carried out using an existing research project at the Ophthalmology Department where forms were created, data were collected and exported and statistical analysis was performed. The flaws in the system ("bugs") were being remedied by the IT team during the tests that were totally satisfactory. Conclusions: The PAEOFTA platform was developed with free access and data security offered by the UNIFESP environment in order to ensure better quality of the data collected in clinical research not only in the Department of Ophthalmology and Visual Sciences but the entire university.
- ItemAcesso aberto (Open Access)Interpretação da patogenicidade e estabelecimento de um banco de dados de variações de número de cópias (cnvs) em uma amostra da população brasileira(Universidade Federal de São Paulo (UNIFESP), 2019-04-25) Godoy, Victoria Cabral Silveira Monteiro De [UNIFESP]; Melaragno, Maria Isabel De Souza Aranha [UNIFESP]; http://lattes.cnpq.br/0678071850781758; http://lattes.cnpq.br/3786115796273447; Universidade Federal de São Paulo (UNIFESP)To survey and classify CNVs, previously identified from arrays performed in our laboratory, in order to build a CNV database of a Brazilian cohort. Methods: A Brazilian cohort of 284 individuals was analyzed, including patients with phenotypic alterations and their unaffected parents. The following array platforms were used: Genome-Wide Human Array 6.0 SNP array (n= 66 individuals), CytoScan High-Density SNP array (n= 163 individuals) and CytoScan 750K (n= 55 individuals), from Affymetrix. Array analyses were performed using the Chromosome Analysis Suite software (ChAS), (Affymetrix, Santa Clara, CA, USA). All arrays that met the QC parameters were included in the analysis and, by using a flowchart, the CNVs were classified according to their pathogenicity. Results: A total of 1,792 CNVs (1,380 gains and 412 losses) were classified as benign (82%), likely benign (3.1%), VUS (5.5%), likely pathogenic (0.2%) and pathogenic (9.2%). Some of the CNVs classified as likely benign or VUS were recurrent and presented an increased frequency. These CNVs could be considered benign in our Brazilian sample, changing the interpretation of their clinical impact. Conclusions: We constructed an internal CNV database of a Brazilian cohort that will be useful for future genomic analyzes in our laboratory. Our study described a high frequency of specific CNVs classified as possibly benign and VUS, and therefore those events were reclassified as benign. In addition, our study established a novel analysis flowchart that was highly effective in classifying the CNVs, even without a phenotype-based classification method.
- ItemSomente MetadadadosPerfil epidemiológico do centro de referência de doenças trofoblásticas do Hospital São Paulo - Universidade Federal de São Paulo - Escola Paulista de Medicina(Universidade Federal de São Paulo (UNIFESP), 2019-11-28) Pimenta, Bruna Sanches Ozane [UNIFESP]; Sun, Sue Yazaki [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Introduction: gestational trophoblastic disease (GTD) is a heterogeneous group of disorders including hydatidiform mole (HM) and gestational trophoblastic neoplasia (GTN) – malignant form that encompasses invasive mole, choriocarcinoma, placental site trophoblastic tumor and epithelioid trophoblastic tumor. The risk of a post-molar GTN is approximatelly 20% after complete mole (CM) and 5% in partial mole (PM). Reported incidence rates of HM show wide geographic and temporal variations. Objectives: the aim of this study was to create a database and to describe and analyse the epidemiological characteristics of patients with GTD treated at São Paulo Hospital gestational trophoblastic disease reference center (RC) within the last 30 years. Methods: review of the medical records of all patients with GTD that received care at the RC between 1990 and 2017. Data collected included: age, ethnicity, number of gestations, parity, gestacional age at molar evacuation, presence of vaginal bleeding, GTD type, molar evacuation at reference center (RC) or elsewhere (NRC), evolution for gestational trophoblastic neoplasia. Significance level was set at p <0.05. Results: a total of 747 medical records were studied resulting in 441 CM, 162 PM, 130 non-classified hydatidiform mole (NCM), 10 GTN without previous hydatidiform mole histopathologically confirmed and 4 twin pregnancy with CM and a normal fetus. Among 603 patients with CM and PM, 62% underwent uterine evacuation at our center, while 38% were referred center after evacuation at NRC. Among RC patients 74% had CM and 26% had PM and among NRC 72% had CM and 28% had PM. The mean age of patients with HM between the periods was higher in the last decade. PM distribution was preferentially from 19 to 40 year-old (yo) and CM at the age groups: < 19 yo and > 40 yo. Clinical symptoms were most frequent in CM, however, recurrence was most evident in PM. Among the HM cases that underwent evacuation at our center, postmolar GTN occurred in 12.3% of the patients with CM and in 7.1% of those with PM. Considering all GTN cases treated at our center, 74% (134/181) had pregnancy index treated in NRC and 26%(47/181) at our center. High-risk GTN cases according FIGO/WHO were mostly originated from NRC (NRC 13.6% - 18/132 x RC 4.3% - 2/47)(p=0,08). Conclusion: high-risk GTN were mostly originated from NRC what may be related to a delayed diagnosis, highlighting the importance of the reference center in improving the GTD treatment.