Navegando por Palavras-chave "B-lymphocytes"

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    Identificação de linfócitos T e B em conjuntivites foliculares e na síndrome de Sjogren
    (Universidade Federal de São Paulo (UNIFESP), 1978) Belfort, Rubens Junior [UNIFESP]; Mendes, Nelson Figueiredo [UNIFESP]
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    Rituximab in refractory autoimmune diseases: Brazilian experience with 29 patients (2002-2004)
    (Clinical & Exper Rheumatology, 2006-01-01) Scheinberg, Morton Aaron [UNIFESP]; Hamerschlak, N.; Kutner, J. M.; Ribeiro, AAF; Ferreira, E.; Goldenberg, José [UNIFESP]; Kiss, M. H.; Chahade, W. H.; Hosp Israel Albert Einstein; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP); Hosp Servidor Estado Sao Paulo
    Objective Rituximab, a monoclonal antibody against B-lymphocytes that express CD 20, is already available for the treatment of non-Hodgkin's lymphoma. Due to the increased relevance of B-cell regulation in the pathogenesis of autoimmune diseases, rituximab is being used in the treatment of patients whose condition is refractory to conventional therapy.Methods We retrospectively evaluated the short-term efficacy and tolerance of rituximab in patients with various autoimmune diseases who were treated at the Hospital Israelita Albert Einstein in the city of Sao Paulo.Results During the period 2002-2004, 29 patients with various autoimmune diseases were treated with rituximab 375 mg/m(2) for 4 consecutive weeks, or two doses of I g 2 weeks apart. We observed remarkable short-term results in all cases, except for one patient with thrombocytopenic purpura. Of note, we describe the results in two patients with diseases not previously treated with rituximab (hypergammaglobulinemic purpura of Waldenstrom and eosinophilic fasciitis with hypergammaglobulinemia). Treatment was well tolerated, with no unexpected adverse events. We also observed a marked reduction in steroid dosage.Conclusion Rituximab seems to be safe and effective in the treatment of patients with a variety of autoimmune diseases that are refractory to other modalities of treatment.