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- ItemEmbargoCurva de referência do volume do braço e coxa fetal por meio da ultrassonografia tridimensional usando o método XI VOCAL(Universidade Federal de São Paulo (UNIFESP), 2011-03-30) Cavalcante, Rafael de Oliveira [UNIFESP]; Araujo Júnior, Edward [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Objective: To determine reference ranges for fetal upper arm and thigh volumes by three-dimensional (3D) ultrasonography using and the eXtended Imaging Virtual Organ Computer-aided AnaLysis method (XI VOCAL) method. Methods: This cross-sectional study enrolled 425 healthy pregnant women between 20 and 40 weeks of gestation. For volumetric calculation, XI VOCAL method was performed in 10 sequential areas along the axial cross-section, having proximal and distal epiphyses as references. In order to evaluate the correlation between fetal limb volume and gestational age (GA) second degree polynomial regression models were created determining the 5th, 10th, 25th, 50th, 75th, 90th and 95th percentiles. Intraclass correlation coefficient (ICC) was used to evaluate intra and interobserver reproducibility. Results: Mean fetal upper arm volume varied from 4.59 ± 1.18 (3.10 – 7.40 cm3) to 53.87 ± 10.72 cm3 (40.30 – 76.60 cm3) and thigh volume from 8.00 ± 1.86 (3.90 – 11.90 cm3) to 122.14 ± 14.90 cm3 (105.0 – 153.50 cm3). Fetal limb volumes were highly associated with GA: upper arm volume = 34.26 – 3.62xGA + 0.11xGA2 (R2= 0.913) and thigh volume = 68.70 – 7.63xGA + 0.23xGA2 (R2= 0.946). Intra and interobserver reproducibility were excellent with an ICC= 0.997 and 0.996, for fetal upper arm and thigh volumes, respectively. Conclusions: The reference ranges of fetal upper arm and thigh volumes were determined by 3D-ultrasound imaging using the XI VOCAL method and were found to be highly reproducible.