Navegando por Palavras-chave "Anxiety-like behavior"
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- ItemSomente MetadadadosChronic REM Sleep Restriction in Juvenile Male Rats Induces Anxiety-Like Behavior and Alters Monoamine Systems in the Amygdala and Hippocampus(Humana Press Inc, 2018) Rocha-Lopes, Janaina da Silva [UNIFESP]; Machado, Ricardo Borges; Suchecki, Deborah [UNIFESP]Adolescence is marked by major physiological changes, including those in the sleep-wake cycle, such as phase delay, which may result in reduced sleep hours. Sleep restriction and/or deprivation in adult rats activate stress response and seem to be a risk factor for triggering emotional disorders. In the present study, we sought to evaluate the behavioral and neurobiological consequences of prolonged REM sleep restriction in juvenile male rats. Immediately after weaning, on postnatal day 21, three males from each litter were submitted to REM sleep deprivation and the other three animals were maintained in their home-cages. REM sleep restriction (REMSR) was accomplished by placing the animals in the modified multiple platform method for 18 h and 6 h in the home-cage, where they could sleep freely
- ItemSomente MetadadadosThe influence of the polyunsaturated fatty acids on body weight and anxiolytic-like behavior in female rats(Maney Publishing, 2013-01-01) Borsonelo, Elizabethe Cristina [UNIFESP]; Vieira, Laila; Galduróz, José Carlos Fernandes; Universidade Federal de São Paulo (UNIFESP)Some studies have showed the benefits of polyunsaturated fatty acids (PUFAs) as a complement in weight loss diets, even though the results are hardly conclusive. Additionally, anxiety is another relevant factor that influences not only the appetite but the locomotion of the animals as well. This study evaluated the effect of a diet enriched with PUFAs in relation to body weight in an animal model of anxiety (the elevated plus maze). Female Wistar rats were allocated to one of four groups and were fed different diets for 30 days: control diet (commercial chow (Nuvilab (R)); diet enriched with fish oil; diet enriched with linseed oil, and diet enriched with soybean oil. the body weight was not influenced by the kind of diet. the group that received food enriched with linseed oil remained in the open arms for longer periods when compared with the control group. This result suggests an anxiolytic-like effect in that group.
- ItemSomente MetadadadosSex and estrous cycle influence diazepam effects on anxiety and memory: Possible role of progesterone(Pergamon-Elsevier Science Ltd, 2016) Silva, Anatildes Feitosa; Sousa, Diego Silveira; Medeiros, André de Macêdo [UNIFESP]; Macedo, Priscila Tavares; Leão, Anderson Henrique França Figueiredo; Ribeiro, Alessandra Mussi [UNIFESP]; Izídio, Geison Souza; Silva, Regina Helena [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Studies with rodents and humans show the relationship between female sex hormones and cognitive/emotional tasks. However, despite the greater incidence of anxiety disorders in women, the data are still inconclusive regarding the mechanisms related to this phenomenon. We evaluated the effects of a classical anxiolytic/amnestic drug (diazepam; DZP) on female (at different estrous cycle phases) and male rats tested in the plus-maze discriminative avoidance task (PMDAT), that allows the concomitant evaluation of memory and anxiety-like behavior. Further, in order to investigate the role of progesterone and its metabolites in the effects of DZP in the PMDAT, female rats were pre-treated with the progesterone receptor antagonist mifepristone or the 5-alpha-reductase inhibitor finasteride. The main findings were: (1) DZP caused memory impairment and anxiolysis in both sexes, but only the highest dose induced the anxiolytic effect in females; (2) females in proestrus did not present the amnestic and anxiolytic effects of DZP (at 2.0 and 4.0 mg/kg, respectively) and (3) the co-administration of mifepristone reestablished both amnestic and anxiolytic effects of DZP, while finasteride reinstated the amnestic effect in proestrus female rats. These results suggest that changes in the endogenous levels of progesterone and its metabolites are important in the modulation of emotional/cognitive behavior in female rats. Based on the influence on different aspects of DZP action, the mechanisms related to this modulation are probably linked to GABAergic transmission, but this point remains to be investigated. Further, the variation in therapeutic and adverse effects of DZP depending on sex and hormonal state is of great relevance considering the higher prevalence of anxiety disorders in women.
- ItemSomente MetadadadosStress during development alters anxiety-like behavior and hippocampal neurotransmission in male and female rats(Elsevier B.V., 2012-01-01) Barbosa Neto, Jair B. [UNIFESP]; Tiba, Paula A. [UNIFESP]; Faturi, Claudia B. [UNIFESP]; Castro-Neto, Eduardo F. de [UNIFESP]; Naffah-Mazacoratti, Maria da Graca [UNIFESP]; Maria, Jair de Jesus [UNIFESP]; Mello, Marcelo F. de [UNIFESP]; Suchecki, Deborah [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade Federal do ABC (UFABC)Epidemiological data indicate that early stress increases vulnerability to psychiatric disorders, including anxiety and depression. in the present study we sought to investigate the long-term behavioral and neurochemical consequences of increased and sustained corticosterone levels induced by a 24 h bout of maternal deprivation (DEP) imposed on postnatal day 11 (DEP11). As adults, animals were exposed to the elevated plus maze for assessment of anxiety-like behavior and corticosterone response to this challenge, or decapitated for determination of monoamines and amino acid neurotransmitters content in the hippocampus by HPLC method. the results showed that DEP11 male and female rats displayed increased time in the central hub of the maze and more risk assessment behavior, reflecting increased anxiety-like behavior; in addition, these animals continuously secreted corticosterone in response to the behavioral test until the latest time-point, e.g., 60 min post-stress. in males, maternal deprivation increased aspartate and glutamate levels and reduced taurine levels compared to non-deprived (NDEP) rats. DEP11 females displayed reduced noradrenaline, aspartate and GABA levels compared to NDEP counterparts. These results indicate that maternal deprivation at 11 days of age produced changes in hippocampal neurotransmission that may mediate the increased anxiety-like behavior observed in male and female deprived rats.This article is part of a Special Issue entitled 'Anxiety and Depression'. (C) 2011 Elsevier B.V. All rights reserved.