Navegando por Palavras-chave "Antocianina"

Agora exibindo 1 - 1 de 1
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Suplementação de juçara (euterpe edulis mart.) Na remodelação da microbiota intestinal, dos parâmetros metabólicos e do estado inflamatório na obesidade
    (Universidade Federal de São Paulo (UNIFESP), 2019-08-28) Gois, Giovana Jamar De Queiroz [UNIFESP]; Pisani, Luciana Pellegrini [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Background: The evidence that the gut microbiota composition may differ between healthy and obese individuals has raised interest in understanding the role of it as an intermediary factor between dietary habits and the pathophysiology of obesity and its comorbidities. Polyphenols-rich fruits and unsaturated fatty acids can reach both obesity and local and systemic low-grade chronic inflammation, besides manipulate bacterial community, improving metabolic functions in humans and animal models of obesity. In this sense, juçara has been considered a "superfruit" due to its nutritional composition and relevant biological activities with interesting response in animals. However, the contribution of this fruit to human physiology remains unknown. Aim: To analyze the effects of juçara supplementation on metabolic and inflammatory parameters, on the composition of gut bacterial species and on short chain fatty acid (SCFA) production in obesity. Methods: This double-blind randomized trial enrolled 35 obese subjects (body mass index - BMI 30 to 39.9 kg/m2) of both sexes aged 31-59 years. They were evaluated for resting metabolic rate (indirect calorimetry); anthropometry (weight, height, BMI, neck and waist circumferences, and waist-toheight ratio); body composition (bioimpedance); blood pressure; food intake (3-day food record); metabolic parameters (TAG, TC, HDL-c, LDL-c, glucose, insulin, and LPS); inflammatory markers (PAI-1, leptin and adiponectin); gut bacteria (qPCR); fecal SCFA (gas chromatography). Subsequently, they were randomized into 2 groups for use or not (placebo) of supplementation with 5 g dry juçara for 6 weeks and reassessed. Results: In metabolism, juçara supplementation was effective in reducing body fat (p = 0.051) and increasing HDL-c (p = 0.046), in addition to doubling serum adiponectin concentration (p = 0.048). Supplementation, HDL-c and neck circumference were predictors for explaining adiponectin increase, regardless of age, gender and body composition. The rise of HDL-c (β = 0.527) favored better adiponectin levels, and supplementation (r2 = 0.477) was crucial for these results. In the intestinal microbiota, there was a significant increase in acetate (g = 0.809; p = 0.038) and in relative abundance of A. muciniphila, Bifidobacterium spp. and C. coccoides in response to juçara supplementation (239.6%, 182.6% and 214%, respectively), with emphasis on the bifidogenic effect as a mediator for stool acetate production (z = 2.925; p = 0.003); showing the prebiotic potential of juçara from the adjustment for total fiber intake. All xresults were independent of food intake. Conclusion: Juçara showed antiinflammatory properties and prebiotic function, contributing to the balance of intestinal microbiota. This supplementation can be considered a new strategy for treating obesity.