Navegando por Palavras-chave "Angiografia Por Ressonância Magnética"

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    Estudo longitudinal para avaliar a evolucao clinica e arteriografica de pacientes com Arterite de Takayasu submetidos ao PET-CT com 18F-FDG
    (Universidade Federal de São Paulo (UNIFESP), 2019-02-28) Janes, Anna Larissa Faria [UNIFESP]; Souza, Alexandre Wagner Silva De [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Introduction. The assessment of disease activity in Takayasu arteritis (TA) is a challenge, since silent progression occurs in patients considered to be in remission. PET-CT scan (Positron Emission Tomography - Computed Tomography) with 18-Fluorodeoxyglucose (18F-FDG) started to be used in the evaluation of disease activity in TA. The uptake of 18F-FDG in arterial walls may reflect the arterial inflammatory process and consequently the disease activity. Methods. In this study, we assessed longitudinally whether the higher uptake of 18F-FDG, measured by the SUV index (Standardized Uptake Value) and the maximum SUV (SUVmax) in arterial walls, is associated with the development of new arterial lesions in TA and reactivation of the disease. Patients who underwent PET-CT scan with 18F-FDG between 2009 and 2010 were reassessed annually by angioresonance and / or computed angiotomography. Results. Of the 36 patients with TA initially recruited, 32 were evaluated longitudinally by a median of 83.5 months. Twenty patients (62.5%) with TA showed disease activity according to PET-CT with 18F-FDG, considering SUVmax ≥ 1.3. The median SUVmax at baseline was 1.57 (1.16-2.23). At follow-up, 23 (71.9%) patients had at least one recurrence of TA and new arterial lesions were observed in 14 (43.8%) cases. There was no difference in the basal SUV value between arteries that developed and arteries that did not develop new lesions in patients with TA. There was a higher frequency of disease recurrences, a greater need to change the immunosuppressive agent and a lower frequency of death in patients with SUVmax ≥1.3. Conclusions. There is no association between arterial SUV and the development of a new arterial lesion in TA, but arterial SUVmax in patients with TA is associated with a higher frequency of disease recurrences and a greater need for changes in immunosuppressive therapy.