Navegando por Palavras-chave "Amlodipine"

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    Antihypertensive efficacy of amlodipine and losartan after two 'missed' doses in patients with mild to moderate essential hypertension
    (Field House Publishing Llp, 2007-11-01) Ribeiro, Artur Beltrame [UNIFESP]; Mion Junior, Decio; Marin, M. J.; Majul, Claudio; Botero, R.; Lopez, N. R.; Gonzalez, S.; Izurieta, H.; Francischetti, Emilio Antonio; Latin Amer Hypertension Study Grp; Universidade Federal de São Paulo (UNIFESP); Policlin Bancario; Hosp Santojanni; Clin Medellin; Ctr Med Docente La Trinidad; Gen Hosp Durango; Ctr Med Alemania; Rio de Janeiro Sch Med; Universidade de São Paulo (USP)
    We compared the effects of amlodipine (5 - 10 mg, n = 94) and losartan (50 100 mg, n = 94) on the lowering of blood pressure (BP) at steady state and after two missed doses, as well as on tolerability. This was a randomized, double-blind study of 12 weeks of active treatment followed by 2 days of placebo treatment. Twenty-four-hour ambulatory blood pressure monitoring and office BP measurements were performed at baseline, week 12 and after the 2-day drug holiday. After 12 weeks, amlodipine was significantly more effective than losartan in reducing both 24-h systolic blood pressure (SBP) (-18.0 versus -10.8 mmHg) and diastolic blood pressure (DBP) (-10.6 versus -8.0 mmHg). While mean SBP and DBP for both treatments increased comparably during the drug holiday, BP values remained significantly lower than baseline for both treatments. The superior BP-lowering effect of amlodipine compared with losartan was maintained during the drug holiday.