Navegando por Palavras-chave "Aminoethanol dihydrogenphosphate"

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    Estudo da encapsulação de 2-aminoetanol-dihidrogenofosfato em sílica mesoporosa altamente ordenada SBA-15 e quitosana
    (Universidade Federal de São Paulo (UNIFESP), 2017-06-02) Segismundo, Natalia Raiz [UNIFESP]; Mercuri, Lucildes Pita [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    The molecule of 2-aminoethanol dihydrogenphosphate (FSF) is popularly known as phosphoethanolamine. This compound is precursor of phosphatidylethanolamine which is the second most abundant lipid in mammals. For many years, phosphoethanolamine has been associated with tumors and neurological disorders. Some authors have reported that FSF would be efficient for tumor reduction. Since some authors have reported that FSF is ineffective when combined with chemotherapeutics, an alternative would be the encapsulation of this compound in substrates that could play the role of protector and carrier of this active. Chitosan (QTS) is a biopolymer produced from the alkaline deacetylation of chitin which has as its main source crustacean shells. This biopolymer has several applications in several areas and it has been used as a drug carrier. The highly ordered mesoporous silica of the SBA-15 type are extremely used for the encapsulation of various substances, mainly drugs, due to their large pore volume, high surface area and greater thermal, mechanical, chemical and hydrothermal stability. In this work two types of phosphoethanolamine [pure (FSF1) and in the form of Ca, Mg and Zn (FSF2) salt] were characterized by the techniques of Elemental Analysis (AE), X-ray diffraction (XRD), Fourier Transform Infrared Absorption Spectroscopy (FTIR), Thermogravimetry/Derivative Thermogravimetry (TG/DTG) and Differential Scanning Calorimetry (DSC). Then, these actives were encapsulated in the supports of QTS and SBA-15 giving rise to the materials QTS/FSF1; QTS/FSF2; SBA-15/FSF1 e SBA-15/FSF2. These were also characterized chemically using AE, FTIR and TG/DTG techniques to evaluate the most effective encapsulation condition. The results of the FSF’s characterization techniques showed that the addition of inorganic elements increased the thermal stability of phosphoethanolamine. The chitosan used in this work presented some impurities when compared to chitosan P.A. The TG/DTG curves of the encapsulations QTS of FSF2 indicated the presence of the active, but it was not possible to quantify the material was encapsulated. For the SBA-15 encapsulations of the two FSF samples, the presence of the active was only verified in the 12 hour agitation time. The best encapsulation condition was of FSF1 active on the QTS support using water as the solvent after 24 hours of agitation and without filtration. Keywords: 2-aminoethanol dihydrogenphosphate, chitosan, SBA-15, encapsulation.