Navegando por Palavras-chave "Alpha-interferon"

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    High incidence of tuberculosis in patients treated for hepatitis C chronic infection
    (Elsevier Brazil, 2016) de Oliveira Uehara, Silvia Naomi [UNIFESP]; Emori, Christini Takemi [UNIFESP]; Perez, Renata Mello; Jacintho Mendes-Correa, Maria Cassia; Paiva Ferreira, Adalgisa de Souza; de Castro Amaral Feldner, Ana Cristina [UNIFESP]; Benedito Silva, Antonio Eduardo [UNIFESP]; Carvalho Filho, Roberto Jose [UNIFESP]; de Souza e Silva, Ivonete Sandra [UNIFESP]; Cardoso Gomes Ferraz, Maria Lucia [UNIFESP]
    Brazil is one of the 22 countries that concentrates 80% of global tuberculosis cases concomitantly to a large number of hepatitis C carriers and some epidemiological risk scenarios are coincident for both diseases. We analyzed tuberculosis cases that occurred during alpha-interferon-based therapy for hepatitis C in reference centers in Brazil between 2001 and 2012 and reviewed their medical records. Eighteen tuberculosis cases were observed in patients submitted to hepatitis C alpha-interferon-based therapy. All patients were human immunodeficiency virus-negative. Nine patients (50%) had extra-pulmonary tuberculosis; 15 (83%) showed significant liver fibrosis. Hepatitis C treatment was discontinued in 12 patients (67%) due to tuberculosis reactivation and six (33%) had sustained virological response. The majority of patients had a favorable outcome but one died. Considering the evidences of alpha-IFN interference over the containment of Mycobacterium tuberculosis, the immune impairment of cirrhotic patients, the increase of tuberculosis case reports during hepatitis C treatment with atypical and severe presentations and the negative impact on sustained virological response, we think these are strong arguments for latent tuberculosis infection screening before starting alpha-interferon-based therapy for any indication and even to consider IFN-free regimens against hepatitis C when a patient tests positive for latent tuberculosis infection. (C) 2016 Elsevier Editora Ltda.