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    A suplementação de L-carnitina não promove alterações na taxa metabólica de repouso e na utilização dos substratos energéticos em indivíduos ativos
    (Sociedade Brasileira de Endocrinologia e Metabologia, 2010-02-01) Coelho, Christianne De Faria; Mota, João Felipe [UNIFESP]; Ravagnani, Fabrício César De Paula; Burini, Roberto Carlos; Universidade de São Paulo (USP); Universidade para o Desenvolvimento do Estado e da Região do Pantanal; Universidade Federal de São Paulo (UNIFESP); Universidade São Francisco Departamento de Nutrição; Universidade Federal do Mato Grosso do Sul; Universidade Católica Dom Bosco; Universidade Estadual Paulista (UNESP)
    PURPOSE: To investigate the effects of L-carnitine supplementation, over thirty days, on the resting metabolic rate (RMR) and oxidation of free fatty acids (FFA) under rested or exercised conditions. SUBJECTS AND METHODS: Twenty-one overweight active volunteers (40 to 58 years old) were randomized into two groups: supplemented (GS; N = 11; 1,8 g/day of L-carnitine) or placebo (GP; N = 10; maltodextrin). Caloric intake, anthropometry, RMR, VO2max, respiratory exchange ratio and plasma FFA were measured. RESULTS: No significant changes were found in the caloric intake (-244,66 vs. -126,00 kcal/day), body composition (-0.07 vs. -0.17 kg/m²), RMR (0.06 vs. -0.02 kcal/day), respiratory exchange ratio at rest (3.69 vs. -1.01) and exercise (0.01 vs. -0.01) or VO2max (0.50 vs. 1.25 mL/kg/min) between GS and GP. Plasma FFA levels were increased under resting conditions only in the GP group (0.27), but no significant changes were observed before or after physical activity in any of the groups. CONCLUSION: Supplementation with L-carnitine caused no changes in the variables analyzed in this study.