PPG - Engenharia Química

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https://hdl.handle.net/11600/61110

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Navegando PPG - Engenharia Química por Autor "Cunha, Bruna Leticia De Carvalho [UNIFESP]"

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    Síntese e caracterização do dímero L-Lactídeo para produção do ácido Poli-L-Láctico visando sua aplicação na área médica
    (Universidade Federal de São Paulo (UNIFESP), 2021) Cunha, Bruna Leticia De Carvalho [UNIFESP]; Concha, Viktor Oswaldo Cárdenas [UNIFESP]; Universidade Federal de São Paulo
    The search for polymers from natural sources has increased exponentially, since they have the potential to replace petroleum-derived polymers. Some of these biopolymers are biodegradable, which have wide application as a biomaterial in the health area. Among them, the Poly Lactic Acid (PLA) stands out for being a biodegradable polyester with excellent physical and biological properties. The main route for obtaining high molar mass PLA has the Lactide dimer as a starting monomer, which is commonly produced by depolymerizing PLA. Currently, there is a lack of knowledge about the Lactide obtaining process and divergences for reaction parameters. In addition, the PLA synthesis from this dimer has a high cost production, since the monomer has high added value. In this context, it is crucial to know the L-Lactide process production for use as a monomer for the synthesis of high molar mass PLA, which is widely used in medical applications. Thus, this work aims to evaluate different experimental configurations for the L-Lactide synthesis process, in order to obtain a monomer with high yield and purity and later scale up of the process. For this purpose, three experimental configurations were carried out in which the temperature of 185°C, pressure of 125 mmHg (manometric vacuum), and reaction time of 4 hours were considered. The L-lactide produced had its thermal and spectroscopic properties characterized by the techniques of differential scanning calorimetry (DSC), infrared spectroscopy with Fourier transform (FTIR), and X-ray diffraction (XRD). Experimental results showed the formation of Lactide in some points of the system (connector between reactor and collecting flask, collecting flask and condenser), whose properties were compatible with the standard L-Lactide (PURASORB® L). From the data obtained on a laboratory scale, the conceptual and basic project for the scale up of the process of obtaining L-Lactide was developed.