PPG - Engenharia Química
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Navegando PPG - Engenharia Química por Orientador(es) "Veggi, Priscilla Carvalho [UNIFESP]"
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- ItemAcesso aberto (Open Access)Avaliação econômica da obtenção de extrato de bagaço de maracujá: uma comparação entre as técnicas de extração com líquido pressurizado e líquido pressurizado assistida por ultrassom(Universidade Federal de São Paulo, 2021-07-15) Ferreira, Wilson Santos [UNIFESP]; Veggi, Priscilla Carvalho [UNIFESP]; Viganó, Juliane; http://lattes.cnpq.br/6020226876173532; http://lattes.cnpq.br/4337428740305589; http://lattes.cnpq.br/8882671734599669Natural products and plant extracts have been widely used in recent years and have a growing and relevant importance in the pharmaceutical, food, and cosmetics sectors, due to the bioactive properties of their compounds. The development of extraction technologies and processes are fundamental to the growth of this sector, especially the extraction with supercritical fluids (SFE), with pressurized liquid (PLE), and ultrasound-assisted extraction (US). In the process design step, the use of simulators is one of the most important steps due to the software's ability to predict the behavior of processes, providing information for the project’s economic feasibility analysis and scale-up scenarios. In this context, this work presents the economic feasibility study of two different extraction processes for obtaining a piceatannol-rich extract from yellow passion fruit bagasse, namely, process A (supercritical fluid extraction + pressurized liquid extraction – SFE+PLE) at 65 and 75 ºC and process B (SFE+PLE assisted by ultrasound – SFE+PLE-US) at 65 ºC and 440 W. The SuperPro Designer® software was employed to estimate the manufacturing cost (COM), productivity, and economic return rates, which were calculated for each overall extraction curve (5 to 300 min) and different scales (50, 200, and 500 L). Scale-up increased productivity and reduced COM, improving the economic return rates. Process A proved to be economically viable, while process B was unfeasible at a minimum acceptable rate of return (MARR) of 20%. The lowest COM and the best economic return were obtained with process A at 75 ºC, 500 L scale, and processing time of 90 min. A sensitivity study was carried out and indicated that it is possible to sell the extract at a price below the market price, representing a competitive differential to implement this process. It is noteworthy that up to now, the economic feasibility of PLE-US on a large scale had not yet been performed, so this work represents a starting point for studies of PLE-US hybridization at large scales.
- ItemAcesso aberto (Open Access)Obtenção de compostos fenólicos da casca do barbatimão (Stryphnodendron adstringens (Mart.) Coville) empregando a extração assistida por ultrassom(Universidade Federal de São Paulo, 2022-02-23) Ribeiro, Maurício Masaru de Souza [UNIFESP]; Veggi, Priscilla Carvalho [UNIFESP]; Viganó, Juliane; http://lattes.cnpq.br/6020226876173532; http://lattes.cnpq.br/4337428740305589; http://lattes.cnpq.br/9814478545352867Diversos estudos vêm demonstrando as capacidades medicinais e terapêuticas do barbatimão (Stryphnodendron adstringens (Mart.) Coville) e associando suas propriedades aos compostos fenólicos obtidos principalmente a partir de sua casca. Contudo, são escassos para o barbatimão estudos voltados a compreender a influência dos processos de extração e de seus parâmetros na obtenção de compostos bioativos. Dentro deste contexto, o presente estudo teve como objetivo empregar a extração assistida por ultrassom (UAE) e avaliar a influência dos parâmetros de processo no rendimento global (X0), nos teores de fenólicos totais (TPC), taninos totais (TTC), flavonoides totais (TFC) e na capacidade antioxidante redutor férrico (FRAP). Foram avaliados também a atividade antioxidante celular e a citotoxicidade dos extratos. Para tanto, foram estudados os parâmetros amplitude (0, 20, 30 e 40%), razão entre massa de matéria-prima (RM) por massa de solvente (S/F de 5, 10, 15, 20 e 25) e tempo de processo (2, 4, 6, 8, 10 e 12 min). As melhores condições de processo para a obtenção de compostos fenólicos da casca do barbatimão por UAE foram com a amplitude de 30%, S/F de 20 e tempo de 8 min, obtendo X0 de 43,39%, TPC de 385,40 mg ETA (ácido tânico equivalente)/g dry RM, TTC de 501,25 mg EP (pirogalol equivalente)/g dry RM, TFC de 243,33 mg EQ (quercetina equivalente)/g dry RM, e FRAP de 472,09 mg ET (trolox equivalente)/g dry RM. A UAE foi comparada às técnicas convencionais de extração por soxhlet e agitação mecânica (MA) que apresentou maiores rendimentos do que o soxhlet. A UAE e MA foram criteriosamente comparadas a fim de verificar os mecanismos envolvidos na UAE, demonstrando que a extração de taninos foi potencializada devido aos efeitos proporcionados pela sonda ultrassônica. O extrato obtido via UAE apresentou 66,67% de atividade antioxidante celular na concentração de extrato de 0,02 mg/mL, concentração na qual não foi apresentado citotoxicidade, apresentando um resultado comparável ao resveratrol e N-acetilcisteína e apresentou viabilidade celular superior a 80%. Estes resultados indicam que a técnica de UAE é uma alternativa viável às técnicas convencionais de extração para a obtenção de compostos fenólicos da casca do barbatimão.
- ItemSomente MetadadadosObtenção de extratos da casca de Barbatimão (Stryphnodendron adstringens) e incorporação em matriz biopolimérica(Universidade Federal de São Paulo (UNIFESP), 2020-12-21) Brito, Vivian Pereira De [UNIFESP]; Veggi, Priscilla Carvalho [UNIFESP]; Universidade Federal de São PauloPlants rich in phenolics compounds have become an interesting subject of research due to its potential applications, for instance, as wound healing agents. These bioactive compounds can be incorporated in a natural polymer matrix to be used in biomedical area. In this context, this study aimed to evaluate the extraction of barbatimão and its incorporation in silk fibroin hydrogels. The barbatimão extracts were obtained by two optimized and adapted extraction methods, the first one using an ultrasonic bath with ethanol 65% (v/v) as solvent and the second one using a stirring bath and propylene glycol 50% (v/v) as solvent. The extract obtained by this last method showed the best results related to global yield, antioxidant capacity through FRAP assay and total phenolic content. The reducing sugar content and the antioxidant capacity through ORAC assay did not present significant statistical difference between the methods studied. The presence of tannins was confirmed, in both extracts, by qualitative analyses. The hydrogels with barbatimão extract were compared to hydrogels containing only the ethanol and the propylene glycol solutions. This propylene glycol hydrogel showed the longest gelation time and a reversible sol-gel transition after few days when manipulated and at room temperature. This result could also be confirmed by FTIR analysis with peaks related to silk I structure. The hydrogels containing ethanol and containing the extracts presented conformations of silk I and II, predominating this last one, by the FTIR spectrum. Thermogravimetric analyses by TGA indicated the highest thermal stability of the hydrogels containing propylene glycol. The incorporation of barbatimão extracts did not significantly affect the Hencky stress and strain and deformation values of the hydrogels. However, in the rheology analysis, the hydrogel with barbatimão extract obtained using a stirring bath and propylene glycol 50% (v/v) as solvent showed the highest G’ and G’’ modulus, which means that there was an improvement in the strength and elasticity. This can be explained by the formation of a compact structure that was confirmed by SEM test as well.