Cardiac Autonomic Dysfunction in Offspring of Hypertensive Parents During Exercise
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Data
2017
Autores
de Almeida, Leonardo Barbosa
Pecanha, Tiago
de Carvalho Mira, Pedro Augusto
de Souza, Livia Victorino [UNIFESP]
da Silva, Lilian Pinto
Martinez, Daniel Godoy
Guedes Freitas, Isabelle Magalhaes
Laterza, Mateus Camaroti
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Offspring of hypertensive parents present autonomic dysfunction at rest and during physiological maneuvers. However, the cardiac autonomic modulation during exercise remains unknown. This study tested whether the cardiac autonomic modulation would be reduced in offspring of hypertensive parents during exercise. Fourteen offspring of hypertensive and 14 offspring of normotensive individuals were evaluated. The groups were matched by age (24.5 +/- 1.0 vs. 26.6 +/- 1.5 years; p=0.25) and BMI (22.8 +/- 0.6 vs. 24.2 +/- 1.0kg/m (2) ; p=0.30). Blood pressure and heart rate were assessed simultaneously during 3min at baseline followed by 3-min isometric handgrip at 30% of maximal voluntary contraction. Cardiac autonomic modulation was evaluated using heart rate variability. Primary variables were subjected to two-way ANOVA (group vs. time). P value<0.05 was considered statistically significant. Blood pressure and heart rate were similar between groups during exercise protocol. In contrast, offspring of hypertensive subjects showed a reduction of SDNN (Basal=34.8 +/- 3.5 vs. 45.2 +/- 3.7ms; Exercise=30.8 +/- 3.3 vs. 41.5 +/- 3.9ms; p group=0.01), RMSSD (Basal=37.1 +/- 3.7 vs. 52.0 +/- 6.0ms; Exercise=28.6 +/- 3.4 vs. 41.9 +/- 5.3ms; p group=0.02) and pNN50 (Basal=15.7 +/- 4.0 vs. 29.5 +/- 5.5%; Exercise=7.7 +/- 2.4 vs. 18.0 +/- 4.3%; p group=0.03) during the exercise protocol in comparison with offspring of normotensive parents. We concluded that normotensive offspring of hypertensive parents exhibit impaired cardiac autonomic modulation during exercise.
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International Journal Of Sports Medicine. Stuttgart, v. 38, n. 14, p. 1105-1110, 2017.