Cardiac Autonomic Dysfunction in Offspring of Hypertensive Parents During Exercise

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dc.citation.issue14
dc.citation.volume38
dc.contributor.authorde Almeida, Leonardo Barbosa
dc.contributor.authorPecanha, Tiago
dc.contributor.authorde Carvalho Mira, Pedro Augusto
dc.contributor.authorde Souza, Livia Victorino [UNIFESP]
dc.contributor.authorda Silva, Lilian Pinto
dc.contributor.authorMartinez, Daniel Godoy
dc.contributor.authorGuedes Freitas, Isabelle Magalhaes
dc.contributor.authorLaterza, Mateus Camaroti
dc.coverageStuttgart
dc.date.accessioned2020-09-01T13:21:04Z
dc.date.available2020-09-01T13:21:04Z
dc.date.issued2017
dc.description.abstractOffspring of hypertensive parents present autonomic dysfunction at rest and during physiological maneuvers. However, the cardiac autonomic modulation during exercise remains unknown. This study tested whether the cardiac autonomic modulation would be reduced in offspring of hypertensive parents during exercise. Fourteen offspring of hypertensive and 14 offspring of normotensive individuals were evaluated. The groups were matched by age (24.5 +/- 1.0 vs. 26.6 +/- 1.5 years; p=0.25) and BMI (22.8 +/- 0.6 vs. 24.2 +/- 1.0kg/m (2) ; p=0.30). Blood pressure and heart rate were assessed simultaneously during 3min at baseline followed by 3-min isometric handgrip at 30% of maximal voluntary contraction. Cardiac autonomic modulation was evaluated using heart rate variability. Primary variables were subjected to two-way ANOVA (group vs. time). P value<0.05 was considered statistically significant. Blood pressure and heart rate were similar between groups during exercise protocol. In contrast, offspring of hypertensive subjects showed a reduction of SDNN (Basal=34.8 +/- 3.5 vs. 45.2 +/- 3.7ms; Exercise=30.8 +/- 3.3 vs. 41.5 +/- 3.9ms; p group=0.01), RMSSD (Basal=37.1 +/- 3.7 vs. 52.0 +/- 6.0ms; Exercise=28.6 +/- 3.4 vs. 41.9 +/- 5.3ms; p group=0.02) and pNN50 (Basal=15.7 +/- 4.0 vs. 29.5 +/- 5.5%; Exercise=7.7 +/- 2.4 vs. 18.0 +/- 4.3%; p group=0.03) during the exercise protocol in comparison with offspring of normotensive parents. We concluded that normotensive offspring of hypertensive parents exhibit impaired cardiac autonomic modulation during exercise.en
dc.description.affiliationUniv Fed Juiz de Fora, Univ Hosp, Cardiovasc Res Unit, Juiz De Fora, Brazil
dc.description.affiliationUniv Fed Juiz de Fora, Univ Hosp, Exercise Physiol, Juiz De Fora, Brazil
dc.description.affiliationUniv Fed Juiz de Fora, Fac Phys Educ & Sports, Juiz De Fora, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Phys Educ & Sport, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Div Nephrol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Div Nephrol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipMinas Gerais Research Foundation (FAPEMIG)
dc.format.extent1105-1110
dc.identifierhttp://dx.doi.org/10.1055/s-0043-119883
dc.identifier.citationInternational Journal Of Sports Medicine. Stuttgart, v. 38, n. 14, p. 1105-1110, 2017.
dc.identifier.doi10.1055/s-0043-119883
dc.identifier.issn0172-4622
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58074
dc.identifier.wosWOS:000418457600008
dc.language.isoeng
dc.publisherGeorg Thieme Verlag Kg
dc.relation.ispartofInternational Journal Of Sports Medicine
dc.rightsAcesso restrito
dc.subjecthypertensionen
dc.subjectautonomic nervous systemen
dc.subjectheredityen
dc.subjectexerciseen
dc.titleCardiac Autonomic Dysfunction in Offspring of Hypertensive Parents During Exerciseen
dc.typeArtigo
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