Synthesis of Silylbiaryl Triflates by Chemoselective Suzuki Reaction
No Thumbnail Available
Date
2017
Authors
Moreira, Barbara V. [UNIFESP]
Muraca, Ana Carolina A. [UNIFESP]
Raminelli, Cristiano [UNIFESP]
relationships.isAdvisorOf
item.page.type-of
Artigo
Journal Title
Journal ISSN
Volume Title
Abstract
A modular approach for the synthesis of functionalized silylbiaryl triflates has been developed. Iodinated silylaryl triflates were prepared via a gram-scale diiodination reaction, followed by a one-flask transformation, in 42-52% overall yield. The iodinated silylaryl triflates were subjected to a novel chemoselective Suzuki reaction with arylboronic acids, using PdCl2(PPh3)(2) as catalyst and K2CO3 as base in THF/H2O (1:1) at 80 degrees C for 24 hours, which afforded silylbiaryl triflates in 47-81% yield.
Description
Citation
Synthesis-Stuttgart. Stuttgart, v. 49, n. 5, p. 1093-1102, 2017.