Now showing items 1-10 of 14

    • Biological and structural comparison of recombinant phospholipase D toxins from Loxosceles intermedia (brown spider) venom 

      Ribeiro, Rodrigo Otavio S.; Chaim, Olga Meiri [UNIFESP]; Silveira, Rafael Bertoni da; Gremski, Luiza Helena [UNIFESP]; Sade, Youssef Bacila; Paludo, Katia Sabrina [UNIFESP]; Senff-Ribeiro, Andrea; Moura, Juliana de; Chavez-Olortegui, Carlos; Gremski, Waldemiro; Nader, Helena B. [UNIFESP]; Veiga, Silvio Sanches (Elsevier B.V., 2007-12-15)
      The clinical features of brown spider bites are the appearance of necrotic skin lesions, which can also be accompanied by systemic involvement, including weakness, vomiting, fever, convulsions, disseminated intravascular ...
    • Biotechnological applications of brown spider (Loxosceles genus) venom toxins 

      Senff-Ribeiro, Andrea; Silva, Paulo Henrique da; Chaim, Olga Meiri [UNIFESP]; Gremski, Luiza Helena [UNIFESP]; Paludo, Katia Sabrina [UNIFESP]; Silveira, Rafael Bertoni da; Gremski, Waldemiro; Mangili, Oldemir Carlos; Veiga, Silvio Sanches (Elsevier B.V., 2008-05-01)
      Loxoscelisin (the term used to define accidents by the bite of brown spiders) has been reported worldwide. Clinical manifestations following brown spider bites are frequently associated with skin degeneration, a massive ...
    • CD36 Shunts Eicosanoid Metabolism to Repress CD14 Licensed Interleukin-1 beta Release and Inflammation 

      Zoccal, Karina F.; Gardinassi, Luiz G.; Sorgi, Carlos A.; Meirelles, Alyne F. G.; Bordon, Karla C. F.; Glezer, Isaias [UNIFESP]; Cupo, Palmira; Matsuno, Alessandra K.; Bollela, Valdes R.; Arantes, Eliane C.; Guimaraes, Francisco S.; Faccioli, Lucia Helena (Frontiers Media Sa, 2018)
      Interleukin (IL)-1 beta is a potential target for treatment of several inflammatory diseases, including envenomation by the scorpion Tityus serrulatus. In this context, bioactive lipids such as prostaglandin (PG)E-2 and ...
    • Cytotoxic, thrombolytic and edematogenic activities of leucurolysin-a, a metalloproteinase from Bothrops leucurus snake venom 

      Gremski, L. H.; Chaim, O. M.; Paludo, K. S.; Sade, Y. B.; Otuki, M. F.; Richardson, M.; Gremski, W.; Sanchez, E. F.; Veiga, S. S. (Elsevier B.V., 2007-07-01)
      Leucurolysin-a (leuc-a), a 23 kDa non-hemorrhagic metalloproteinase, is found in venom of the viper Bothrops leucurus. Here, we examine the biological consequences of leuc-a, including thrombolytic activity, direct effects ...
    • Distribution of I-125-labeled crotamine in mice tissues 

      Boni-Mitake, M.; Costa, H.; Vassilleff, S.; Rogero, J. R. (Elsevier B.V., 2006-10-01)
      Crotamine is a strong basic polypeptide from Crotalus durissus terrificus (Cdt) venom composed of 42 amino acid residues tightly bound by three disulfide bonds. It causes skeletal muscle spasms leading to spastic paralysis ...
    • The effect of brown spider venom on endothelial cell morphology and adhesive structures 

      Paludo, Katia Sabrina; Gremski, Luiza Helena; Veiga, Silvio Sanches; Chaim, Olga Meiri; Gremski, Waldemiro; Freitas Buchi, Dorly de; Nader, Helena Bonciani; Dietrich, Carl Peter; Franco, Celia Regina Cavichiolo [UNIFESP] (Elsevier B.V., 2006-06-15)
      Spiders of the Loxosceles genus have been responsible for severe clinical cases of envenomation worldwide. Accidents involving brown spiders can cause dermonecrotic injury, hemorrhage, hemolysis, platelet aggregation and ...
    • Identification and partial characterisation of hyaluronidases in Lonomia obliqua venom 

      Gouveia, AID; Silveira, R. B. da; Nader, H. B.; Dietrich, C. P.; Gremski, W.; Veiga, S. S. (Elsevier B.V., 2005-03-15)
      By studying Lonomia obliqua (caterpillar) venom we were able to detect a lytic activity on purified hyaluronic acid. the venom hydrolyses purified chondroitin sulphate, but was unable to degrade either heparan sulphate or ...
    • Identification of bradykinins in solitary wasp venoms 

      Konno, K.; Palma, M. S.; Hitara, I. Y.; Juliano, M. A.; Juliano, L.; Yasuhara, T. (Elsevier B.V., 2002-03-01)
      Bradykinins were identified in three solitary wasp venoms. Purification and characterization of the venom extract of the scoliid wasp Megacampsomeris prismatica led to the identification of bradykinin and threonine(6)-bradykinin ...
    • Identification, cloning and functional characterization of a novel dermonecrotic toxin (phospholipase D) from brown spider (Loxosceles intermedia) venom 

      Appel, Marcia Helena; Silveira, Rafael Bertoni da [UNIFESP]; Chaim, Olga Meiri [UNIFESP]; Paludo, Katia Sabrina; Silva, Dilza Trevisan; Chaves, Daniele M.; Silva, Paulo Henrique da; Mangili, Oldernir C.; Senff-Ribeiro, Andrea; Gremski, Waldemiro; Nader, Helena B. [UNIFESP]; Veiga, Silvio Sanches (Elsevier B.V., 2008-02-01)
      Brown spider bites are associated with lesions including dermonecrosis, gravitational spreading and a massive inflammatory response, along with systemic problems that may include hematological disturbances and renal failure. ...
    • Identification, cloning, expression and functional characterization of an astacin-like metalloprotease toxin from Loxosceles intermedia (brown spider) venom 

      Silveira, Rafael B.da; Wille, Ana C. M.; Chaim, Olga Meiri [UNIFESP]; Appel, Marcia H.; Silva, Dilza T.; Franco, Celia R. C.; Toma, Leny [UNIFESP]; Mangili, Oldemir C.; Gremski, Waldemiro; Dietrich, Carl Peter [UNIFESP]; Nader, Helena Bonciani [UNIFESP]; Veiga, Silvio S. (Portland Press Ltd, 2007-09-01)
      Injuries caused by brown spiders (Loxosceles genus) are associated with dermonecrotic lesions with gravitational spreading and systemic manifestations. the venom has a complex composition containing many different toxins, ...