Browsing by Subject "melanoma"
Now showing items 1-10 of 37
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AC-1001 H3 CDR peptide induces apoptosis and signs of autophagy in vitro and exhibits antimetastatic activity in a syngeneic melanoma model
(Wiley, 2016)Antibody-derived peptides modulate functions of the immune system and are a source of anti-infective and antitumor substances. Recent studies have shown that they comprise amino acid sequences of immunoglobulin ...
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Análise imuno-histoquímica da expressão das proteínas kit, brafv600e, ciclina d1, pten e myc em melanoma extensivo superficial in situ e fino (1 mm de espessura)
(Universidade Federal de São Paulo (UNIFESP), 2016-10-26)Cutaneous melanoma (CM) is a malignant tumor arising from the uncontrolled proliferation of melanocytes. Although it represents only 3% to 5% of skin neoplasia,it accounts for 65% of deaths from cutaneous neoplasia. In ...
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Antagonista do receptor b1 de bradicinina inibe a nefrotoxicidade induzida por cisplatina em modelo de melanoma murino
(Universidade Federal de São Paulo (UNIFESP), 2015-12-31)A cisplatina ainda é um dos tratamentos mais utilizados contra diferentes tumores sólidos, sendo seu uso limitado pela nefrotoxicidade e o risco do desenvolvimento de lesão renal aguda (LRA). Tendo em vista que o receptor ...
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Antifungal and antitumor models of bioactive protective peptides
(Academia Brasileira de Ciências, 2009-09-01)Peptides are remarkably reactive molecules produced by a great variety of species and able to display a number of functions in uni-and multicellular organisms as mediators, agonists and regulating substances. Some of them ...
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Avaliação da aplicação de complexos de ferro-fenantrolina em terapia fotodinâmica de câncer de melanoma metastático
(Universidade Federal de São Paulo, 2023-01-09)A terapia fotodinâmica (TFD) surgiu como uma vantajosa alternativa para o tratamento de câncer e infecções ao usar fotossensibilizadores para causar danos menos severos nas células e tecidos saudáveis. Apesar de diversos ...
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Avaliação da heterogeneidade intratumoral e intermetástases do éxon 15 do gene braf (7q34) em amostras de melanoma metastático
(Universidade Federal de São Paulo (UNIFESP), 2015-06-05)Introduction: Approximately a half of cutaneous melanoma has a BRAF V600E mutation and benefits from treatment with BRAF and MEK inhibitors, showing rapid tumor regression. However, most of these patients had progression ...
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Avaliação do anticorpo monoclonal g12f2 para reação de imuno-histoquímica do melanoma murino b16f10
(Universidade Federal de São Paulo (UNIFESP), 2015-02-25)In 2006, at the Department of Microbiology, Immunology and Parasitology of Federal University of São Paulo - UNIFESP, was developed a new monoclonal antibody (mAb), type IgM, designated G12F2, which recognized a single ...
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Avaliação do potencial antitumoral de peptídeos baseados em sequências hipervariáveis de imunoglobulinas: atividade antitumoral e mecanismo de ação in vitro e in vivo do peptídeo c36 derivado do vl cdr1 (l1), sobre o melanoma murino b16f10-nex2
(Universidade Federal de São Paulo (UNIFESP), 2015-02-28)Malignant melanoma is a lethal type of skin cancer that is largely resistant to conventional therapies. Recently, monoclonal antibodies (MAbs) have been used in therapy, mainly those reative with immune regulatory receptors. ...
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Characterization of individuals at high risk of developing melanoma in Latin America: bases for genetic counseling in melanoma
(Nature Publishing Group, 2016)Purpose: CDKN2A is the main high-risk melanoma-susceptibility gene, but it has been poorly assessed in Latin America. We sought to analyze CDKN2A and MC1R in patients from Latin America with familial and sporadic multiple ...
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Community-based network analyses reveal emerging connectivity patterns of protein-protein interactions in murine melanoma secretome
(Juan J Calvete, 2021-02-10)Protein-protein interaction networks (PPINs) are static representations of protein connections in which topological features such as subgraphs (communities) may contain proteins functionally related, revealing an additional ...
