Now showing items 1-9 of 9

    • AGE DEPENDENCY of the SUSCEPTIBILITY of RATS TO AMINOOXYACETIC ACID SEIZURES 

      Turski, W.; Dziki, M.; Parada, J.; Kleinrok, Z.; Cavalheiro, E. A. (Elsevier B.V., 1992-06-19)
      Immature rats are more susceptible to clonic seizures induced by aminooxyacetic acid (AOAA) than mature and senile rats. Highest susceptibility to AOAA seizures was observed in 7-14-day-old rat pups. the lowest susceptibility ...

    • AUTORADIOGRAPHIC ANALYSIS of D-1 and D-2 DOPAMINERGIC RECEPTORS in RAT-BRAIN AFTER PARADOXICAL SLEEP-DEPRIVATION 

      Nunes, G. P.; Tufik, S.; Nobrega, J. N. (Elsevier B.V., 1994-01-01)
      Previous work had shown that paradoxical sleep deprivation (PSD) results in potentiation of several apomorphine-induced behaviors, leading to the suggestion that PSD induces an upre,oulation of brain dopamine receptors. ...

    • Chemopreventive Activity of Systemically Administered Curcumin on Oral Cancer in the 4-Nitroquinoline 1-Oxide Model 

      Goncalves, Vinicius de Paiva; Ortega, Adriana Alicia C.; Guimaraes, Morgana R.; Curylofo, Fabiana Almeida; Rossa Junior, Carlos; Ribeiro, Daniel Araki [UNIFESP]; Spolidorio, Luis C. (Wiley-Blackwell, 2015-05-01)
      Curcumin has therapeutic potential in preventing several types of cancer, including colon, liver, prostate, and breast. the goal of this study was to evaluate the chemopreventive activity of systemically administered ...

    • DECREASED MUSCARINIC RECEPTOR-BINDING in RAT-BRAIN AFTER PARADOXICAL SLEEP-DEPRIVATION - AN AUTORADIOGRAPHIC STUDY 

      Nunes, G. P.; Tufik, S.; Nobrega, J. N. (Elsevier B.V., 1994-05-09)
      Previous work demonstrated that paradoxical sleep deprivation (PSD) leads to a decrease in yawning behavior elicited by cholinergic agonists, suggesting that a downregulation of cholinergic muscarinic receptors may occur ...

    • EFFECT OF AGE ON ANTINOCICEPTIVE EFFECTS OF ELEVATED PLUS-MAZE EXPOSURE 

      Frussa-Filho, Roberto [UNIFESP]; Otoboni, JR; Giannotti, A. D.; Amaral, ACS; Conceição, Isaltino Marcelo da [UNIFESP] (Assoc Bras Divulg Cientifica, 1992-01-01)
      It has been suggested that anxiety may be a critical factor in certain forms of non-opioid environmental analgesia. Furthermore, age has been reported to increase the anxiety levels in rats as measured in the elevated ...

    • EFFECTS of STRESS ON DRUG-INDUCED YAWNING - CONSTANT VS INTERMITTENT STRESS 

      Tufik, S.; Nathan, C. D.; Neumann, B.; Hipolide, D. C.; Lobo, L. L.; Demedeiros, R.; Troncone, LRP; Braz, S.; Suchecki, D. (Elsevier B.V., 1995-07-01)
      Experiment 1 tested whether chronic exposure to immobilization, foot shock or forced swimming would result in suppression of apomorphine, pilocarpine-, and physostigmine-induced yawning. Immobilization caused suppression ...

    • EFFECTS OF THE IMMUNOSUPPRESSANT FK506 ON A PENETRATING KERATOPLASTY REJECTION MODEL IN THE RAT 

      Nishi, Mauro [UNIFESP]; Herbort, C. P.; Matsubara, M.; Morishita, Y.; Nishimura, M.; Nieda, M.; Mori, Satomi [UNIFESP]; Mochizuki, M. (Lippincott-raven Publ, 1993-07-01)
      Purpose. The immunosuppressive effects of FK506 on allogeneic corneal transplantation were tested in a rat model.Methods. Inbred-strain Lewis rats were used as recipients, and Fisher rats were used as donors. Intraperitoneal ...

    • REVERSIBLE EFFECTS of ACUTE and LONG-TERM ADMINISTRATION of DELTA-9-TETRAHYDROCANNABINOL (THC) ON MEMORY in the RAT 

      Nakamura, Ester Miyuki [UNIFESP]; Da Silva, Eroy Aparecida [UNIFESP]; Concilio, Germana Valéria [UNIFESP]; Wilkinson, D. Adrian; Masur, Jandira [UNIFESP] (Elsevier B.V., 1991-08-01)
      A study was designed to develop a measure of both acute and chronic effects of THC administration on memory in the rat. Errors in an 8-arm radial maze, before and after two delay intervals (5 s and 1 h, introduced between ...

    • SUPPRESSION OF PILOCARPINE-INDUCED STATUS EPILEPTICUS AND THE LATE DEVELOPMENT OF EPILEPSY IN RATS 

      Lemos, Tadeu [UNIFESP]; Cavalheiro, Esper Abrão [UNIFESP] (Springer, 1995-01-01)
      Status epilepticus (SE) has been related to subsequent development of epilepsy. The present work was aimed at elucidating the relationship between the duration of pilocarpine- (PILO)-induced SE and the subsequent development ...