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    • IRS2 silencing increases apoptosis and potentiates the effects of ruxolitinib in JAK2(V617F)-positive myeloproliferative neoplasms 

      Campos, Paula de Melo; Machado-Neto, Joao A.; Eide, Christopher A.; Savage, Samantha L.; Scopim-Ribeiro, Renata; Souza Duarte, Adriana da Silva; Favaro, Patricia [UNIFESP]; Lorand-Metze, Irene; Costa, Fernando F.; Tognon, Cristina E.; Druker, Brian J.; Olalla Saad, Sara T.; Traina, Fabiola (Impact Journals Llc, 2016)
      The recurrent V617F mutation in JAK2 (JAK2(V617F)) has emerged as the primary contributor to the pathogenesis of myeloproliferative neoplasms (MPN). However, the lack of complete response in most patients treated with the ...