Browsing by Subject "Anoikis"
Now showing items 1-10 of 19
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Acquisition of anoikis resistance promotes alterations in the Ras/ERK and PI3K/Akt signaling pathways and matrix remodeling in endothelial cells
(Springer, 2017)Anoikis is a programmed cell death induced upon cell detachment from extracellular matrix. Anoikis resistance is a critical mechanism in tumor metastasis. Cancer cells deregulate and adapt their metabolism to survive in ...
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Associação entre Timp1, β1-integrinas e CD63 ao longo da gênese do melanoma
(Universidade Federal de São Paulo (UNIFESP), 2010-11-24)Although malignant melanoma is the less frequently diagnosed skin cancer, it shows a poor prognosis due its chemoresistance and metastasis development. One of the adquired abilities of transformed cells is anoikis resistance ...
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Avaliação funcional do gene PIK3CA (fosfatidilinositol-3-quinase, subunidade catalítica alfa) em células endoteliais resistentes ao Anoikis
(Universidade Federal de São Paulo (UNIFESP), 2019-12-18)The development, differentiation and homeostasis of adherent cells are controlled by cell-cell, cell-extracellular matrix (ECM) and cell-soluble factors interactions. The loss of these contacts induces to anoikis, an ...
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Brown spider (Loxosceles intermedia) venom triggers endothelial cells death by anoikis
(Elsevier B.V., 2012-09-01)Brown spider (Loxosceles sp.) venom affects the endothelium of vessels and triggers disruptive activity in the subendothelial matrix. the vascular disorders observed after venom exposure include leukocyte and platelet ...
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Efeito da resistência à morte celular por perda de adesão (anoikis) na expressão do sindecam-4 e no ciclo celular de células endoteliais em cultura
(Universidade Federal de São Paulo, 2013-04-25)Tumors produce several molecules that facilitate their proliferation, invasion and maintenance, especially proteoglycans. The syndecan-4, a heparan sulfate proteoglycan, can act as a co-receptor of growth factors and ...
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Endothelial nitric oxide synthase uncoupling as a key mediator of melanocyte malignant transformation associated with sustained stress conditions
(Elsevier B.V., 2011-05-15)Melanoma cell lines and cells corresponding to premalignant melanocytes were established by our group after subjecting a nontumorigenic murine melanocyte lineage, melan-a, to sequential cycles of anchorage blockade. Previous ...
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Estudo das enzimas envolvidas na biossíntese do heparam sulfato e ácido hialurônico em células endoteliais resistentes ao anoikis após silenciamento gênico do sindecam-4
(Universidade Federal de São Paulo, 2023-08-31)Anoikis é um tipo de morte celular programada desencadeada pela perda de adesão da célula a matriz extracelular ou perda da interação entre as células. A regulação da resistência ao anoikis envolve mecanismos complexos, ...
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Estudos dos efeitos de concentrações crescentes de óxido nitrico no processo de morte por perda de adesão ao substrato (Anoikis): o papel desempenhado no processo pela proteína Src quinase
(Universidade Federal de São Paulo (UNIFESP), 2017-05-30)The study of cell death induced by loss of adhesion (anoikis) is essential to understand how metastatic tumor cells may develop resistance to this type of cell death. Among a number of factors that can influence anoikis, ...
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Expressão De Glicosaminoglicanos Sulfatados E Proteoglicanos De Heparam Sulfato Em Células Endoteliais Resistentes Ao Anoikis Após Tratamento Com Trastuzumabe
(Universidade Federal de São Paulo (UNIFESP), 2018-03-29)To Evaluate The Effect Of Trastuzumab On The Expression Of Sulfated Glycosaminoglycans And Heparan Sulfate Proteoglycans. In Anoikis Resistant Endothelial Cells. Methods: Endothelial Cells Derived From Rabbit Aorta (Ec), ...
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Expressão de moléculas da matriz extracelular em células endoteliais resistentes ao anoikis
(Universidade Federal de São Paulo, 2016-04-19)The extracellular matrix (ECM) is a structure composed of several macromolecules that are differently distributed among tissues of organisms. The interaction between ECM molecules and receptors present on the cell membrane ...
