Análise comparativa da volumetria dos ventrículos laterais cerebrais de fetos com ventriculomegalia por meio da ultrassonografia tridimensional e ressonância magnética
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Data
2010
Autores
Haratz, Karina Krajden [UNIFESP]
Orientadores
Moron, Antonio Fernandes [UNIFESP]
Tipo
Dissertação de mestrado
Título da Revista
ISSN da Revista
Título de Volume
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Objetivos: Mensuracao do volume dos ventriculos laterais cerebrais de fetos com ventriculomegalia pela ultrassonografia tridimensional (US3D) -metodo VOCAL- e da Ressonancia Magnetica Fetal (RM) para avaliacao da concordancia entre metodos e reprodutibilidade. Metodo: Estudo e corte transversal que avaliou 30 fetos com diagnostico de ventriculomegalia (VM) entre 20 e 36 6/7 semanas gestacionais. Cada ventriculo (VL) foi medido inicialmente por dois observadores para comparacao entre metodos e posteriormente por mais dois observadores para avaliacao de reprodutibilidade. Os exames ultrassonograficos foram realizados em aparelho ACCUVIX XQ (Medison, Coreia do Sul) com software VOCAL 30º e as RM em sistema Sonata de 1,5T (Siemens, Alemanha) com software ARGUS. Os VL foram estratificados conforme sua posicao em relacao ao transdutor e o tamanho do atrio ventricular. Para estudo de concordancia e reprodutibilidade intra e interobservador calculamos os coeficientes de correlacao intraclasse (CCI) e contruimos Graficos de Bland-Altman. Resultados: Todos os VL foram adequadamente medidos pela ressonancia magnetica (RM) e 59 pelo metodo VOCAL. Os dados obtidos pelo VOCAL e pela RM apresentaram excelente concordancia geral (CCI 0,928, IC 95% [0,876;0,958]) e em todas as categorias analisadas. Os graficos de Bland- Altman confirmaram estes achados com media das diferencas: 1,62cm3 e desvio=padrao:± 8,41 cm3 na analise geral. Nao foram observadas diferencas significativas entre ventriculos distais e proximais. Os ventriculos acima de 30cm3 apresentam discrepancias maiores devido a artefatos de imagem. Conclusoes: A volumetria dos VL pelo VOCAL e pela RM apresenta excelente concordancia e reprodutibilidade. Ventriculos acima de 30cm3 apresentam
Objective: Ventricular atria conventional measurement in the axial plane alone has proven not to give information about ventriculomegaly (VM) etiology nor prognosis. Our aim was to evaluate lateral ventricles morphology of VM / hydrocephaly fetuses using 3D-US renderization by VOCALô technique and MRI and verify morphologic patterns related to etiology. Methods: 17 fetuses presenting with ventricular enlargement (atria >10mm) were submitted to sonographic and MRI exams. Threedimensional datasets were acquired with ACCUVIX XQô ultrasound system (Medison, Korea), from a coronal reference plane and postprocessed by the rotational imaging program VOCALô 30o . The ventricular volume was measured and 3D ventricular reconstruction was then exhibited in the screen. MRI study was analyzed in the three plans in all sequences (T1, T2 and T2 gradient). Morphologic aspects as global shape, anterior, posterior and inferior horn characteristics, wall irregularities and deformities were analyzed and related to etiology factor. Results: 29% of the cases were secondary to Arnold-Chiari Syndrome and presented with global dilation of the three-horns, regular ventricular walls keeping the ventricular shape. Cases related to aqueduct stenosis presented with ependymal rupture and wall irregularities in advances cases. Ventricular shape was rounder with important enlargement of the body and posterior horn. Corpus callosum agenesis cases presented with small ventricular volumes, thin shape, normal or slightly enlarged anterior and inferior horns with dilation restricted to posterior horn. Cases related to trisomy 18 and cytomegalovirus presented irregular ventricular walls associated with anomalous ventricular shapes, suggesting parenchymal destruction. Conclusion: Ventricular morphology evaluation gives important information on etiology of ventricular enlargement, supporting prognosis prediction and decision making process of the affected fetuses and their families.
Objective: Ventricular atria conventional measurement in the axial plane alone has proven not to give information about ventriculomegaly (VM) etiology nor prognosis. Our aim was to evaluate lateral ventricles morphology of VM / hydrocephaly fetuses using 3D-US renderization by VOCALô technique and MRI and verify morphologic patterns related to etiology. Methods: 17 fetuses presenting with ventricular enlargement (atria >10mm) were submitted to sonographic and MRI exams. Threedimensional datasets were acquired with ACCUVIX XQô ultrasound system (Medison, Korea), from a coronal reference plane and postprocessed by the rotational imaging program VOCALô 30o . The ventricular volume was measured and 3D ventricular reconstruction was then exhibited in the screen. MRI study was analyzed in the three plans in all sequences (T1, T2 and T2 gradient). Morphologic aspects as global shape, anterior, posterior and inferior horn characteristics, wall irregularities and deformities were analyzed and related to etiology factor. Results: 29% of the cases were secondary to Arnold-Chiari Syndrome and presented with global dilation of the three-horns, regular ventricular walls keeping the ventricular shape. Cases related to aqueduct stenosis presented with ependymal rupture and wall irregularities in advances cases. Ventricular shape was rounder with important enlargement of the body and posterior horn. Corpus callosum agenesis cases presented with small ventricular volumes, thin shape, normal or slightly enlarged anterior and inferior horns with dilation restricted to posterior horn. Cases related to trisomy 18 and cytomegalovirus presented irregular ventricular walls associated with anomalous ventricular shapes, suggesting parenchymal destruction. Conclusion: Ventricular morphology evaluation gives important information on etiology of ventricular enlargement, supporting prognosis prediction and decision making process of the affected fetuses and their families.
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Citação
Haratz, Karina Krajden. Análise comparativa da volumetria dos ventrículos laterais cerebrais de fetos com ventriculomegalia por meio da ultrassonografia tridimensional e ressonância magnética. 2010. 144 f. Dissertação (Mestrado em Ciências) - Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, 2010.