Exercise-Induced Abnormal Increase of Systolic Pulmonary Artery Pressure in Adult Patients With Sickle Cell Anemia: An Exercise Stress Echocardiography Study

Página do item simplificado
dc.citation.issue12
dc.citation.volume33
dc.contributor.authorLima-Filho, Newton Nunes de [UNIFESP]
dc.contributor.authorFigueiredo, Maria Stella [UNIFESP]
dc.contributor.authorVicari, Perla [UNIFESP]
dc.contributor.authorCancado, Rodolfo
dc.contributor.authorCarvalho, Antonio Carlos de Camargo [UNIFESP]
dc.contributor.authorBordin, Jose Orlando
dc.contributor.authorCampos, Orlando [UNIFESP]
dc.coverageHoboken
dc.date.accessioned2020-07-31T12:47:05Z
dc.date.available2020-07-31T12:47:05Z
dc.date.issued2016
dc.description.abstractBackground: Pulmonary hypertension (PH) at rest is a risk factor for death in patients with sickle cell anemia (SCA). Exercise echocardiography (EE) can detect latent PH. We sought to investigate the occurrence of exercise-induced abnormal response of systolic pulmonary artery pressure (SPAP) in adult patients with SCA and normal SPAP at rest, and to identify the independent predictors of this abnormal response. Methods and Results: Forty-four adult patients with SCA and normal SPAP at rest (tricuspid regurgitant jet flow velocity [TRV] < 2.5 m/sec) were studied and divided into 2 groups: exhibiting normal SPAP after treadmill EE (TRV <= 2.7 m/sec) (G1), and exhibiting abnormal exercise-induced increase of SPAP (TRV > 2.7 m/sec) (G2). TRV cutoff points at rest and during EE were based on data from healthy-matched control subjects. Abnormal response of SPAP with exercise occurred in 57% of the sample (G2), with mean TRV level of 3.39 +/- 0.41 m/sec (range 2.8-4.5 m/sec), significantly higher than those of G1 (2.29 +/- 0.25 m/sec, range 2.0-2.7 m/secen
dc.description.abstractP < 0.001). Multivariate analysis identified TRV value in resting conditions >= 2.25 m/sec (P < 0.05), left atrial volume index >= 41 mL/m(2) (P < 0.05), and a E/e'-waves ratio >= 6.3 (P < 0.05) as independent predictors of exercise-induced increase of SPAP. Conclusion: We concluded that adult patients with SCA and normal SPAP at rest may exhibit abnormal exercise-induced increase in SPAP, which was independently related to resting TRV levels, and indices of diastolic impairment and left ventricular filling pressure.en
dc.description.affiliationUniv Sao Paulo UNIFESP, Paulista Sch Med Fed, Div Cardiol, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo UNIFESP, Sch Medicine Fed, Hematol Div Paulista, Sao Paulo, Brazil
dc.description.affiliationHoly House Mercy Sao Paulo, Div Hematol, Sao Paulo, Brazil
dc.description.affiliationUnifespCardiology Division, Paulista School of Medicine‐Universidade Federal de São Paulo (UNIFESP), Sao Paulo, Brazil
dc.description.affiliationUnifespHematology Division of Paulista School of Medicine‐Universidade Federal de São Paulo (UNIFESP), Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent1880-1890
dc.identifierhttp://dx.doi.org/10.1111/echo.12853
dc.identifier.citationEchocardiography-A Journal Of Cardiovascular Ultrasound And Allied Techniques. Hoboken, v. 33, n. 12, p. 1880-1890, 2016.
dc.identifier.doi10.1111/echo.12853
dc.identifier.issn0742-2822
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56573
dc.identifier.wosWOS:000395405600014
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofEchocardiography-A Journal Of Cardiovascular Ultrasound And Allied Techniques
dc.rightsAcesso restrito
dc.subjectpulmonary hypertensionen
dc.subjectexercise echocardiographyen
dc.subjectsickle cell anemiaen
dc.titleExercise-Induced Abnormal Increase of Systolic Pulmonary Artery Pressure in Adult Patients With Sickle Cell Anemia: An Exercise Stress Echocardiography Studyen
dc.typeArtigo
Arquivos
Coleções
EPM - Artigos