Combination of a high-fat diet with sweetened condensed milk exacerbates inflammation and insulin resistance induced by each separately in mice

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dc.citation.volume7]
dc.contributor.authorMasi, Laureane Nunes
dc.contributor.authorMartins, Amanda Roque
dc.contributor.authorCrisma, Amanda Rabello
dc.contributor.authorAmaral, Catia Lira do
dc.contributor.authorDavanso, Mariana Rodrigues
dc.contributor.authorAfonso Serdan, Tamires Duarte
dc.contributor.authorSá, Roberta Dourado Cavalcante da Cunha de [UNIFESP]
dc.contributor.authorCruz, Maysa Mariana [UNIFESP]
dc.contributor.authorAlonso-Vale, Maria Isabel Cardoso [UNIFESP]
dc.contributor.authorTorres, Rosângela Pavan
dc.contributor.authorMancini-Filho, Jorge
dc.contributor.authorBertaglia Pereira, Joice Naiara
dc.contributor.authorda Silva Righetti, Marta Maria
dc.contributor.authorLiberti, Edson Aparecido
dc.contributor.authorHirabara, Sandro Massao
dc.contributor.authorCuri, Rui
dc.coverageLondon
dc.date.accessioned2020-06-26T16:30:35Z
dc.date.available2020-06-26T16:30:35Z
dc.date.issued2017
dc.description.abstractObesogenic diets increase body weight and cause insulin resistance (IR), however, the association of these changes with the main macronutrient in the diet remains to be elucidated. Male C57BL/6 mice were fed with: control (CD), CD and sweetened condensed milk (HS), high-fat (HF), and HF and condensed milk (HSHF). After 2 months, increased body weight, glucose intolerance, adipocyte size and cholesterol levels were observed. As compared with CD, HS ingested the same amount of calories whereas HF and HSHF ingested less. HS had increased plasma AST activity and liver type I collagen. HF caused mild liver steatosis and hepatocellular damage. HF and HSHF increased LDL-cholesterol, hepatocyte and adipocyte hypertrophy, TNF-alpha by macrophages and decreased lipogenesis and adiponectin in adipose tissue (AT). HSHF exacerbated these effects, increasing IR, lipolysis, mRNA expression of F4/80 and leptin in AT, Tlr-4 in soleus muscle and IL-6, IL-1 beta, VCAM-1, and ICAM-1 protein in AT. The three obesogenic diets induced obesity and metabolic dysfunction. HS was more proinflammatory than the HF and induced hepatic fibrosis. The HF was more detrimental in terms of insulin sensitivity, and it caused liver steatosis. The combination HSHF exacerbated the effects of each separately on insulin resistance and AT inflammatory state.en
dc.description.affiliationUniv Cruzeiro Sul, Interdisciplinary Postgrad Program Hlth Sci, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo, Brazil
dc.description.affiliationState Univ Goias, Campus Exact Sci & Technol, Anapolis, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Inst Biomed Sci, Dept Biol Sci, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Pharmaceut Sci, Dept Food & Expt Nutr, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Biomed Sci, Dept Anat, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Inst Biomed Sci, Dept Biol Sci, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt
dc.description.sponsorshipGuggenheim Foundation
dc.format.extent-
dc.identifierhttps://dx.doi.org/10.1038/s41598-017-04308-1]
dc.identifier.citationScientific Reports. London, v. 7, p. -, 2017.
dc.identifier.doi10.1038/s41598-017-04308-1
dc.identifier.fileWOS000403840000009.pdf
dc.identifier.issn2045-2322
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53643
dc.identifier.wosWOS:000403840000009
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofScientific Reports
dc.rightsAcesso aberto
dc.titleCombination of a high-fat diet with sweetened condensed milk exacerbates inflammation and insulin resistance induced by each separately in miceen
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