Single-nucleotide polymorphisms in genes related to the hypothalamic-pituitary-adrenal axis as risk factors for posttraumatic stress disorder

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dc.citation.issue7
dc.citation.volume174
dc.contributor.authorCarvalho, Carolina M [UNIFESP].
dc.contributor.authorCoimbra, Bruno M. [UNIFESP]
dc.contributor.authorOta, Vanessa K. [UNIFESP]
dc.contributor.authorMello, Marcelo F. [UNIFESP]
dc.contributor.authorBelangero, Sintia I. [UNIFESP]
dc.coverageHoboken
dc.date.accessioned2020-08-04T13:39:57Z
dc.date.available2020-08-04T13:39:57Z
dc.date.issued2017
dc.description.abstractPosttraumatic stress disorder (PTSD) is a common psychiatric disorder. The etiology of PTSD is multifactorial, depending on many environmental and genetic risk factors, and the exposure to life or physical integrity-threatening events. Several studies have shown significant correlations of many neurobiological findings with PTSD. Hypothalamic-pituitary-adrenal (HPA) axis dysfunction is strongly correlated with this disorder. One hypothesis is that HPA axis dysfunction may precede the traumatic event, suggesting that genes expressed in the HPA axis may be involved in the development of PTSD. This article reviews molecular genetic studies related to PTSD collected through a literature search performed in PubMed, MEDLINE, ScienceDirect, and Scientific Electronic Library Online (SciELO). The results of these studies suggest that several polymorphisms in the HPA axis genes, including FKBP5, NR3C1, CRHR1, and CRHR2, may be risk factors for PTSD development or may be associated with the severity of PTSD symptoms.en
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Psychiat, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Morphol & Genet, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, LINC Interdisciplinary Lab Clin Neurosci, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Dept Psychiat, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Dept Morphol & Genet, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, LINC Interdisciplinary Lab Clin Neurosci, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo [FAPESP 2014/12559-5, 07280-1]
dc.description.sponsorshipIDFAPESP: 2014/12559-5
dc.description.sponsorshipIDFAPESP: 2014/07280-1]
dc.format.extent671-682
dc.identifierhttp://dx.doi.org/10.1002/ajmg.b.32564
dc.identifier.citationAmerican Journal Of Medical Genetics Part B-Neuropsychiatric Genetics. Hoboken, v. 174, n. 7, p. 671-682, 2017.
dc.identifier.doi10.1002/ajmg.b.32564
dc.identifier.issn1552-4841
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57201
dc.identifier.wosWOS:000417426700002
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofAmerican Journal Of Medical Genetics Part B-Neuropsychiatric Genetics
dc.rightsAcesso restrito
dc.subjectgeneen
dc.subjectHPA axisen
dc.subjectpolymorphismsen
dc.subjectPTSDen
dc.subjecttraumaen
dc.titleSingle-nucleotide polymorphisms in genes related to the hypothalamic-pituitary-adrenal axis as risk factors for posttraumatic stress disorderen
dc.typeArtigo
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