Effect of nicotine treatment and withdrawal on random-pattern skin flaps in rats

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dc.contributor.authorCampos, Jose Humberto O.
dc.contributor.authorGomes, Heitor Carvalho [UNIFESP]
dc.contributor.authordos-Santos, Washington L. C.
dc.contributor.authorCardeal, Mauricio
dc.contributor.authorFerreira, Lydia Masako [UNIFESP]
dc.contributor.institutionEscola Bahiana Med & Saude Publ
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionFundacao Oswaldo Cruz
dc.date.accessioned2016-01-24T13:51:40Z
dc.date.available2016-01-24T13:51:40Z
dc.date.issued2008-09-01
dc.description.abstractBackground: Tobacco use is associated with a high incidence of skin necrosis after surgery. the ideal timing for the cessation of tobacco use before plastic surgery has not, however, been precisely determined. the aim of this work was to define the ideal duration of nicotine withdrawal prior to random-pattern skin flap surgery in rats.Methods: Groups of 11 animals were subcutaneously injected with saline or nicotine (2 mg/kg) twice a day and subjected to random-pattern skin flap surgery according to the following protocol: Group I: continuously injected with saline 4 weeks before and I week after the surgery; Group II: injected with nicotine for 4 weeks until the day of the surgery; Group III: injected with nicotine for 4 weeks until one day before the surgery; Group IV: injected with nicotine for 4 weeks until 5 days before the surgery; Group V: injected with nicotine for 4 weeks until 10 days before the Surgery; Group VI: continuously injected with nicotine for 4 weeks before and I week after the surgery. McFARLANE skin flaps were performed on the dorsal skin, and the rats were sacrificed I week after the surgery.Results: the necrotic area was smaller in group I (8.85 cm(2)) than in group II (12.15 cm(2)), III (12.88 cm(2)) and VI (14.84 cm(2)) (ANOVA p < 0.0001). There was no difference between groups I, IV (10.13 cm(2)) and V (9.27 cm(2)).Conclusions: in conclusion, 5 days before surgery was considered the ideal time for nicotine withdrawal in this experimental model. (C) 2008 Published by Elsevier GmbH.en
dc.description.affiliationEscola Bahiana Med & Saude Publ, BR-40290000 Salvador, BA, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, BR-04023900 São Paulo, Brazil
dc.description.affiliationFundacao Oswaldo Cruz, Ctr Pesquisas Goncalo Moniz, Salvador, BA, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent449-452
dc.identifierhttp://dx.doi.org/10.1016/j.etp.2008.02.004
dc.identifier.citationExperimental and Toxicologic Pathology. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 60, n. 6, p. 449-452, 2008.
dc.identifier.doi10.1016/j.etp.2008.02.004
dc.identifier.issn0940-2993
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30886
dc.identifier.wosWOS:000259659800004
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofExperimental and Toxicologic Pathology
dc.rightsAcesso restrito
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectnicotineen
dc.subjectMcFARLANE skin flapsen
dc.subjectnecrosisen
dc.subjecttobaccoen
dc.subjectratsen
dc.titleEffect of nicotine treatment and withdrawal on random-pattern skin flaps in ratsen
dc.typeArtigo
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