A GSTP1 functional variant associated with cocaine dependence in a Brazilian population

Página do item simplificado
dc.contributor.authorGuindalini, Camila [UNIFESP]
dc.contributor.authorO'Gara, Colin
dc.contributor.authorLaranjeira, Ronaldo [UNIFESP]
dc.contributor.authorCollier, David
dc.contributor.authorCastelo, Adauto [UNIFESP]
dc.contributor.authorVallada, Homero [UNIFESP]
dc.contributor.authorBreen, Gerome
dc.contributor.institutionKings Coll London
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-18T11:26:59Z
dc.date.available2018-06-18T11:26:59Z
dc.date.issued2005-12-01
dc.description.abstractCocaine dependence aetiology is complex and genetically influenced. We hypothesize that, for many users, efficient metabolism of cocaine and its toxic byproducts aids persistent cocaine use, such as that leading to dependence. The glutathione-S-transferases-in particular, GST-Pi-may be important in preventing cocaine and alcohol-induced oxidative damage. We genotyped a GST-Pi functional polymorphism (Ile105Val) in 654 male cocaine users and 572 controls from Brazil. Genotype and allele frequencies of Ile105Val differed significantly (chi(2) = 6.74; P=0.03 and chi(2)=6.54; P=0.01, respectively). Ile/Ile cocaine dependents had an OR=1.31 (95%Cl: 1.04-1.65), and Ile/Ile dependents consuming > 50 units alcohol weekly an OR of 1.44 (95% CI:106-1.96). Population stratification was assessed and did not affect the results. These data require replication but do suggest that the high activity Ile105 GST-Pi allele may influence the aetiology and development of cocaine dependence.en
dc.description.affiliationKings Coll London, Sect Genet, MRC, Social Genet & Dev Psychiat Res Ctr,Inst Psychiat, London SE5 8AF, England
dc.description.affiliationKings Coll London, Dept Psychol Med, Inst Psychiat, London SE5 8AF, England
dc.description.affiliationUniv Sao Paulo, Sch Med, Dept Psychiat, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, UNIAD, Dept Psychiat, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, UNIAD, Dept Psychiat, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent891-893
dc.identifierhttp://dx.doi.org/10.1097/01213011-200512000-00007
dc.identifier.citationPharmacogenetics And Genomics. Philadelphia: Lippincott Williams & Wilkins, v. 15, n. 12, p. 891-893, 2005.
dc.identifier.doi10.1097/01213011-200512000-00007
dc.identifier.issn1744-6872
dc.identifier.urihttp://repositorio.unifesp.br/11600/45086
dc.identifier.wosWOS:000233534800007
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofPharmacogenetics And Genomics
dc.rightsAcesso restrito
dc.subjectcocaine dependenceen
dc.subjectGSTP1en
dc.subjectpolymorphismen
dc.subjectaddiction geneticsen
dc.subjectalcoholen
dc.subjectfunctionalen
dc.subjectoxidativeen
dc.titleA GSTP1 functional variant associated with cocaine dependence in a Brazilian populationen
dc.typeArtigo
Arquivos
Coleções
EPM - Artigos