Small leucine-rich proteoglycans (SLRPs) in the endometrium of polycystic ovary syndrome women: a pilot study

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dc.contributor.authorSimoes, Ricardo Santos
dc.contributor.authorSoares-, Jose Maria, Jr.
dc.contributor.authorSimoes, Manuel J.
dc.contributor.authorNader, Helena B.Bruna Linzmeyer
dc.contributor.authorBaracat, Maria Candida P.
dc.contributor.authorMaciel, Gustavo Arantes R.
dc.contributor.authorSerafini, Paulo C.
dc.contributor.authorAzziz, Ricardo
dc.contributor.authorBaracat, Edmund C.
dc.date.accessioned2019-08-19T11:49:45Z
dc.date.available2019-08-19T11:49:45Z
dc.date.issued2017
dc.description.abstractBackground: Small leucine-rich proteoglycans (SLRPs) play an important role in tissue homeostasis and cell proliferation since these proteoglycans sequester multiple growth factors. However, the content of SLRPs in the endometrium of polycystic ovary syndrome (PCOS) women is unknown. Our purpose was to test the hypothesis that excessive endometrial proliferation in PCOS may be partly related to abnormalities in SLRPs. Methods: In a cross section study a total of 20 endometrial samples were collected from 10 patients with PCOS and 10 ovulatory women during their proliferative (pre-ovulatory) phase. The study subjects were matched for age, body mass index and race. The age range was 20 to 35 years. All volunteers were evaluated in reproductive endocrinology clinic, Gynecology Division, Clinics Hospital, University of Sao Paulo Medical School Profile and concentration of small leucine-rich proteoglycans (decorin, lumican, fibromodulin and biglycan) were determined by immunohistochemical testing and Western blotting. Results: Decorin and lumican demonstrated higher immunoreactivity and relative expression in the endometrium of women with PCOS compared to that of women with regular menstrual cycles. Conclusion: Our data suggests that the endometrium of PCOS women demonstrate a greater content of SLRP than controlsen
dc.description.abstractdecorin and lumican, in particular, were found in higher concentrations in the endometrium of PCOS women during the proliferative phase. These differences may, in part, explain the excess of endometrial proliferation frequently observed in PCOS. Further studies are warranted.en
dc.description.affiliationUniv São Paulo, Fac Med, Disciplina Ginecol, Dept Obstet & Ginecol,Hosp Clin, São Paulo, Brazil
dc.description.affiliationUniv Fed São Paulo, Dept Mol Biol, São Paulo, Brazil
dc.description.affiliationAugusta Univ, Med Coll Georgia, Dept Obstet & Gynecol, Augusta, GA USA
dc.description.affiliationAugusta Univ, Med Coll Georgia, Dept Med, Augusta, GA USA
dc.description.affiliationAve Dr Eneas de Carvalho Aguiar 255, BR-05403900 São Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed São Paulo, Dept Mol Biol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFAPESP (Brasilia - Brazil)
dc.description.sponsorshipCAPES (Brasilia - Brazil)
dc.description.sponsorshipIDFapesp: 2009/54019-9
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1186/s13048-017-0349-9
dc.identifier.citationJournal Of Ovarian Research. London, v. 10, p. -, 2017.
dc.identifier.doi10.1186/s13048-017-0349-9
dc.identifier.fileWOS000407714300001.pdf
dc.identifier.issn1757-2215
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/51396
dc.identifier.wosWOS:000407714300001
dc.language.isoeng
dc.publisherBiomed Central Ltd
dc.rightsAcesso aberto
dc.subjectPolycystic ovary syndromeen
dc.subjectEndometriumen
dc.subjectSmall leucine-rich proteoglycansen
dc.subjectProliferative phaseen
dc.titleSmall leucine-rich proteoglycans (SLRPs) in the endometrium of polycystic ovary syndrome women: a pilot studyen
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