Low-level laser therapy and light-emitting diode effects in the secretion of neuropeptides SP and CGRP in rat skin

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dc.contributor.authorHochman, Bernardo Sergio [UNIFESP]
dc.contributor.authorPinfildi, Carlos Eduardo [UNIFESP]
dc.contributor.authorNishioka, Michele Akemi [UNIFESP]
dc.contributor.authorFurtado, Fabianne [UNIFESP]
dc.contributor.authorBonatti, Silvilena [UNIFESP]
dc.contributor.authorMonteiro, Paola K. P. [UNIFESP]
dc.contributor.authorAntunes, Arainy S. [UNIFESP]
dc.contributor.authorEspírito Santo, Paulo Rogério Quieregatto do [UNIFESP]
dc.contributor.authorLiebano, Richard Eloin [UNIFESP]
dc.contributor.authorChadi, Gerson
dc.contributor.authorFerreira, Lydia Masako [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T14:37:14Z
dc.date.available2016-01-24T14:37:14Z
dc.date.issued2014-05-01
dc.description.abstractThe phototherapy effects in the skin are related to biomodulation, usually to accelerate wound healing. However, there is no direct proof of the interrelation between the effects of low-level laser therapy (LLLT) and light-emitting diode (LED) in neuropeptide secretion, these substances being prematurely involved in the neurogenic inflammation phase of wound healing. This study therefore focused on investigating LLLT and LED in Calcitonin gene-related peptide (CGRP) and substance P (SP) secretion in healthy rat skin. Forty rats were randomly distributed into five groups with eight rats each: Control Group, Blue LED Group (470 nm, 350 mW power), Red LED Group (660 nm, 350 mW power), Red Laser Group (660 nm, 100 mW power), and Infrared Laser Group (808 nm, 100 mW power) (DMCA (R) Equipamentos Ltda., So Carlos, So Paulo, Brazil). the skin of the animals in the experimental groups was irradiated using the punctual contact technique, with a total energy of 40 J, single dose, standardized at one point in the dorsal region. After 14 min of irradiation, the skin samples were collected for CGRP and SP quantification using western blot analysis. SP was released in Infrared Laser Group (p = 0.01); there was no difference in the CGRP secretion among groups. Infrared (808 nm) LLLT enhances neuropeptide SP secretion in healthy rat skin.en
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, BR-04023002 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Neurol, BR-01246903 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, BR-04023002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent1203-1208
dc.identifierhttps://dx.doi.org/10.1007/s10103-013-1494-z
dc.identifier.citationLasers in Medical Science. London: Springer London Ltd, v. 29, n. 3, p. 1203-1208, 2014.
dc.identifier.doi10.1007/s10103-013-1494-z
dc.identifier.issn0268-8921
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37715
dc.identifier.wosWOS:000337248300045
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofLasers in Medical Science
dc.rightsAcesso restrito
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectWestern blottingen
dc.subjectLasersen
dc.subjectNerve endingsen
dc.subjectNeurogenic inflammationen
dc.subjectPhotobiologyen
dc.subjectPhototherapyen
dc.titleLow-level laser therapy and light-emitting diode effects in the secretion of neuropeptides SP and CGRP in rat skinen
dc.typeArtigo
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