Comparison of Different Spectral Domain OCT Scanning Protocols for Diagnosing Preperimetric Glaucoma

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dc.contributor.authorLisboa, Renato [UNIFESP]
dc.contributor.authorParanhos Junior, Augusto [UNIFESP]
dc.contributor.authorWeinreb, Robert N.
dc.contributor.authorZangwill, Linda M.
dc.contributor.authorLeite, Mauro Toledo [UNIFESP]
dc.contributor.authorMedeiros, Felipe Andrade [UNIFESP]
dc.contributor.institutionUniv Calif San Diego
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:31:37Z
dc.date.available2016-01-24T14:31:37Z
dc.date.issued2013-05-01
dc.description.abstractPURPOSE. To compare the ability of spectral-domain optical coherence tomography (SDOCT) retinal nerve fiber layer (RNFL), optic nerve head (ONH), and macular measurements to detect preperimetric glaucomatous damage.METHODS. the study included 142 eyes from 91 patients suspected of having the disease based on the appearance of the optic disc. All eyes had normal visual fields before the imaging session. Forty-eight eyes with progressive glaucomatous damage were included in the preperimetric glaucoma group. Ninety-four eyes without any evidence of progressive glaucomatous damage and followed untreated for 12.8 +/- 3.6 years were used as controls. Areas under the receiver operating characteristic curves (AUC) were calculated to summarize diagnostic accuracies of the parameters.RESULTS. the three RNFL parameters with the largest AUCs were average RNFL thickness (0.89 +/- 0.03), inferior hemisphere average thickness (0.87 +/- 0.03), and inferior quadrant average thickness (0.85 +/- 0.03). the three ONH parameters with the largest AUCs were vertical cup-to-disc ratio (0.74 +/- 0.04), rim area (0.72 +/- 0.05), and rim volume (0.72 +/- 0.05). the three macular parameters with the largest AUCs were GCC average thickness (0.79 +/- 0.04), GCC inferior thickness (0.79 +/- 0.05), and GCC superior thickness (0.76 +/- 0.05). Average RNFL thickness performed better than vertical cup-to-disc ratio (0.89 vs. 0.74; P = 0.007) and GCC average thickness (0.89 vs. 0.79; P = 0.015).CONCLUSIONS. SDOCT RNFL measurements performed better than ONH and macular measurements for detecting preperimetric glaucomatous damage in a cohort of glaucoma suspects.en
dc.description.affiliationUniv Calif San Diego, Hamilton Glaucoma Ctr, Dept Ophthalmol, La Jolla, CA 92093 USA
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipNational Institutes of Health/National Eye Institute
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipResearch to Prevent Blindness (New York, New York)
dc.description.sponsorshipAlcon
dc.description.sponsorshipAllergan
dc.description.sponsorshipPfizer
dc.description.sponsorshipMerck
dc.description.sponsorshipSanten
dc.description.sponsorshipIDNational Institutes of Health/National Eye Institute: EY021818
dc.description.sponsorshipIDNational Institutes of Health/National Eye Institute: EY11008
dc.description.sponsorshipIDNational Institutes of Health/National Eye Institute: EY14267
dc.description.sponsorshipIDCAPES: 1066/11-0
dc.format.extent3417-3425
dc.identifierhttp://dx.doi.org/10.1167/iovs.13-11676
dc.identifier.citationInvestigative Ophthalmology & Visual Science. Rockville: Assoc Research Vision Ophthalmology Inc, v. 54, n. 5, p. 3417-3425, 2013.
dc.identifier.doi10.1167/iovs.13-11676
dc.identifier.issn0146-0404
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36244
dc.identifier.wosWOS:000321118300039
dc.language.isoeng
dc.publisherAssoc Research Vision Ophthalmology Inc
dc.relation.ispartofInvestigative Ophthalmology & Visual Science
dc.rightsAcesso aberto
dc.subjectpreperimetricen
dc.subjectglaucomaen
dc.subjectdiagnosisen
dc.titleComparison of Different Spectral Domain OCT Scanning Protocols for Diagnosing Preperimetric Glaucomaen
dc.typeArtigo
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