High oxygen extraction and slow recovery of muscle deoxygenation kinetics after neuromuscular electrical stimulation in COPD patients

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dc.citation.issue10
dc.citation.volume116
dc.contributor.authorAzevedo, Diego de Paiva
dc.contributor.authorMedeiros, Wladimir Musetti [UNIFESP]
dc.contributor.authorManfredi de Freitas, Flavia Fernandes
dc.contributor.authorAmorim, Cesar Ferreira
dc.contributor.authorGimenes, Ana Cristina Oliveira [UNIFESP]
dc.contributor.authorNeder, Jose Alberto [UNIFESP]
dc.contributor.authorChiavegato, Luciana Dias [UNIFESP]
dc.coverageNew York
dc.date.accessioned2020-07-31T12:47:41Z
dc.date.available2020-07-31T12:47:41Z
dc.date.issued2016
dc.description.abstractIt was hypothesized that patients with chronic obstructive pulmonary disease (COPD) would exhibit a slow muscle deoxygenation (HHb) recovery time when compared with sedentary controls. Neuromuscular electrical stimulation (NMES 40 and 50 mA, 50 Hz, 400 A mu s) was employed to induce isometric contraction of the quadriceps. Microvascular oxygen extraction (A mu O2EF) and HHb were estimated by near-infrared spectroscopy (NIRS). Recovery kinetic was characterized by measuring the time constant Tau (HHb-tau). Torque and work were measured by isokinetic dynamometry in 13 non-hypoxaemic patients with moderate-to-severe COPD [SpO(2) = 94.1 +/- 1.6 %en
dc.description.abstractFEV1 (% predict) 48.0 +/- 9.6en
dc.description.abstractGOLD II-III] and 13 age- and sex-matched sedentary controls. There was no desaturation in either group during NMES. Torque and work were reduced in COPD versus control for 40 and 50 mA [torque (Nm) 50 mA = 28.9 +/- 6.9 vs 46.1 +/- 14.2en
dc.description.abstractwork (J) 50 mA = 437.2 +/- 130.0 vs. 608.3 +/- 136.8en
dc.description.abstractP < 0.05 for all]. High A mu O2EF values were observed in the COPD group at both NMES intensities (corrected by muscle mass 50 mA = 6.18 +/- 1.1 vs. 4.68 +/- 1.0 %/kgen
dc.description.abstractcorrected by work 50 mA = 0.12 +/- 0.05 vs. 0.07 +/- 0.02 %/Jen
dc.description.abstractP < 0.05 for all). Absolute values of HHb-tau (50 mA = 31.11 +/- 9.27 vs. 18.08 +/- 10.70 s), corrected for muscle mass (50 mA 3.80 +/- 1.28 vs. 2.05 +/- 1.45 s/kg) and corrected for work (50 mA = 0.08 +/- 0.04 vs. 0.03 +/- 0.02 s/J) were reduced in COPD (P < 0.05 for all). The variables behaviour for 40 mA was similar to those of 50 mA. COPD patients exhibited a slower muscle deoxygenation recovery time after NMES. The absence of desaturation, low torque and work, high A mu O2EF and high values for recovery time corrected by muscle mass and work suggest that intrinsic muscle dysfunction has an impact on muscle recovery capacity.en
dc.description.affiliationUniv Sao Paulo UNICID, Masters & Doctoral Program Phys Therapy, Sao Paulo, SP, Brazil
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Div Resp Med, Pulm Funct & Clin Exercise Physiol Unit, Rua Prof Francisco de Castro 54, BR-04020050 Sao Paulo, Brazil
dc.description.affiliationUnifespPulmonary Function and Clinical Exercise Physiology Unit, Division of Respiratory Medicine, Universidade Federal de São Paulo (UNIFESP), Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1899-1910
dc.identifierhttp://dx.doi.org/10.1007/s00421-016-3442-7
dc.identifier.citationEuropean Journal Of Applied Physiology. New York, v. 116, n. 10, p. 1899-1910, 2016.
dc.identifier.doi10.1007/s00421-016-3442-7
dc.identifier.issn1439-6319
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57008
dc.identifier.wosWOS:000384213500004
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofEuropean Journal Of Applied Physiology
dc.rightsAcesso restrito
dc.subjectLung diseaseen
dc.subjectSkeletal muscleen
dc.subjectDeoxyhaemoglobinen
dc.subjectOxygen consumptionen
dc.subjectMetabolismen
dc.subjectExerciseen
dc.titleHigh oxygen extraction and slow recovery of muscle deoxygenation kinetics after neuromuscular electrical stimulation in COPD patientsen
dc.typeArtigo
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