Association of serum interleukin-6 with mental health problems in children exposed to perinatal complications and social disadvantage

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dc.contributor.authorMansur, Rodrigo B. [UNIFESP]
dc.contributor.authorCunha, Graccielle R. [UNIFESP]
dc.contributor.authorAsevedo, Elson [UNIFESP]
dc.contributor.authorZugman, Andre [UNIFESP]
dc.contributor.authorRizzo, Lucas B. [UNIFESP]
dc.contributor.authorGrassi-Oliveira, Rodrigo
dc.contributor.authorLevandowski, Mateus L.
dc.contributor.authorGadelha, Ary [UNIFESP]
dc.contributor.authorPan, Pedro M. [UNIFESP]
dc.contributor.authorTeixeira, Antonio L.
dc.contributor.authorMcIntyre, Roger S.
dc.contributor.authorMari, Jair J. [UNIFESP]
dc.contributor.authorRohde, Luis A.
dc.contributor.authorMiguel, Euripedes C.
dc.contributor.authorBressan, Rodrigo A. [UNIFESP]
dc.contributor.authorBrietzke, Elisa [UNIFESP]
dc.date.accessioned2019-07-22T15:46:53Z
dc.date.available2019-07-22T15:46:53Z
dc.date.issued2016
dc.description.abstractThere is consistent evidence that inflammation is involved in mental disorders pathogenesis. Herein, using data from the High Risk Cohort Study for Psychiatric Disorders, we investigated the relationship between parental mood disorders (PMD), environmental factors, serum interleuldn-6 (IL6) and mental health problems in children aged 6-12. We measured the serum levels of IL6 in 567 children. Information related to socio-demographic characteristics, mental health problems and multiple risk factors, as well as parent's psychiatric diagnosis, was captured. We evaluated two groups of environmental risk factors (i.e. perinatal complications and social disadvantage) using a cumulative risk model. Results showed that higher serum levels of IL6 were associated with PMD (RR = 1.072, p = 0.001), perinatal complications (RR = 1.022, p = 0.013) and social disadvantage (RR = 1.024, p = 0.021). There was an interaction between PMD and social disadvantage (RR = 1.141, p = 0.021), as the effect of PMD on 16 was significantly higher in children exposed to higher levels of social disadvantage. Moreover, there was a positive correlation between IL6 and mental health problems (RR = 1.099, p = 0.026), which was moderated by exposure to perinatal complications or social disadvantage (RR = 1.273, p = 0.015 and RR = 1.179, p = 0.048, respectively). In conclusions, there is evidence of a differential inflammatory activation in children with PMD and exposure to environmental risk factors, when compared to matched peers. Systemic inflammation may be involved in the pathway linking familial risk and mental health problems. (C) 2016 Elsevier Ltd. All rightsen
dc.description.affiliationCNPq, Natl Inst Dev Psychiat Children & Adolescents, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Psychiat, PRISMA Program Recognit & Intervent Individuals R, Sao Paulo, Brazil
dc.description.affiliationUniv Toronto, Univ Hlth Network, Mood Disorders Psychopharmacol Unit, Toronto, ON, Canada
dc.description.affiliationUniv Tubingen, Dept Psychiat, Tubingen, Germany
dc.description.affiliationPontificia Univ Catolica Rio Grande do Sul, Inst Biomed Res, Porto Alegre, RS, Brazil
dc.description.affiliationUniv Fed Minas Gerais, Interdisciplinary Lab Med Invest, Belo Horizonte, MG, Brazil
dc.description.affiliationUniv Fed Rio Grande do Sul, Dept Psychiat, Porto Alegre, RS, Brazil
dc.description.affiliationUniv Sao Paulo, Dept Psychiat, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Dept Psychiat, PRISMA Program Recognit & Intervent Individuals R, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipNational Council for Scientific and Technological Development (CNPq)
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP)
dc.format.extent94-101
dc.identifierhttp://dx.doi.org/10.1016/j.psyneuen.2016.05.015
dc.identifier.citationPsychoneuroendocrinology. Oxford, v. 71, p. 94-101, 2016.
dc.identifier.doi10.1016/j.psyneuen.2016.05.015
dc.identifier.issn0306-4530
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/51143
dc.identifier.wosWOS:000381163000012
dc.language.isoeng
dc.publisherPergamon-Elsevier Science Ltd
dc.rightsAcesso restrito
dc.subjectFamilial mood disorderen
dc.subjectPerinatal complicationsen
dc.subjectSocial disadvantageen
dc.subjectMental health problemsen
dc.subjectInflammationen
dc.subjectChildrenen
dc.titleAssociation of serum interleukin-6 with mental health problems in children exposed to perinatal complications and social disadvantageen
dc.typeArtigo
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