Effects of maternal separation on baseline sleep and cold stress-induced sleep rebound in adult Wistar rats

Página do item simplificado
dc.contributor.authorTiba, Paula Ayako [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorSuchecki, Deborah [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-18T12:12:00Z
dc.date.available2018-06-18T12:12:00Z
dc.date.issued2004-09-15
dc.description.abstractStudy Objectives: To evaluate the influence of early life environments on basal and cold stress-induced sleep patterns in rats.Design: The design was a 3 (Groups [control, early handling, maternal separation]) x 2 (Situations [basal, poststress]) x 11 (Time-blocks) factorial design. From postnatal days 2 to 14, whole litters were either submitted to early handling (15 minutes per day away from the mother) or maternal separation (180 minutes per day away from the mother). At 75 to 90 days of age, sleep was recorded for 22 hours (beginning at 9:00 AM) before and after 1 hour of cold stress (4degreesC).Subjects: Wistar male rats (n = 7-10 animals per group).Measurements and Results: Sleep was analyzed in blocks of 2 hours, in 30-second epochs, separately in the daytime and night-time sleep recordings. Maternally separated rats exhibited more paradoxical sleep at baseline, compared to both control and early-handled rats. In the first 2 hours following the end of cold stress, all groups showed a decrease in paradoxical sleep, whereas slow-wave sleep was reduced only in the control group. The highest corticosterone plasma concentration was observed immediately after stress. Sleep rebound after stress was equally manifested in all groups in the dark part of the light-dark cycle.Conclusions: Maternal separation during early infancy resulted in permanent changes of the sleep architecture reflected by augmented time spent in paradoxical sleep. Although these findings were not expected in light of the literature, they emphasize the importance of the early familiar environment on future behavior of rats.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychobiol, BR-04024002 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psychobiol, BR-04024002 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1146-1153
dc.identifierhttps://doi.org/10.1093/sleep/27.6.1146
dc.identifier.citationSleep. Westchester: Amer Academy Sleep Medicine, v. 27, n. 6, p. 1146-1153, 2004.
dc.identifier.issn0161-8105
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/45613
dc.identifier.wosWOS:000224445600015
dc.language.isoeng
dc.publisherAmer Academy Sleep Medicine
dc.relation.ispartofSleep
dc.rightsAcesso aberto
dc.subjectearly handlingen
dc.subjectmaternal separationen
dc.subjectstressen
dc.subjectsleepen
dc.subjectsleep rebounden
dc.subjectraten
dc.titleEffects of maternal separation on baseline sleep and cold stress-induced sleep rebound in adult Wistar ratsen
dc.typeArtigo
Arquivos
Coleções
EPM - Artigos