Cannabidiol, among Other Cannabinoid Drugs, Modulates Prepulse Inhibition of Startle in the SHR Animal Model: Implications for Schizophrenia Pharmacotherapy

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dc.contributor.authorPeres, Fernanda F. [UNIFESP]
dc.contributor.authorLevin, Raquel [UNIFESP]
dc.contributor.authorAlmeida, Valeria [UNIFESP]
dc.contributor.authorZuardi, Antonio W.
dc.contributor.authorHallak, Jaime E.
dc.contributor.authorCrippa, Jose A.
dc.contributor.authorAbilio, Vanessa C. [UNIFESP]
dc.date.accessioned2019-07-22T15:46:34Z
dc.date.available2019-07-22T15:46:34Z
dc.date.issued2016
dc.description.abstractSchizophrenia is a severe psychiatric disorder that involves positive, negative and cognitive symptoms. Prepulse inhibition of startle reflex (PPI) is a paradigm that assesses the sensorimotor gating functioning and is impaired in schizophrenia patients as well as in animal models of this disorder. Recent data point to the participation of the endocannabinoid system in the pathophysiology and pharmacotherapy of schizophrenia. Here, we focus on the effects of cannabinoid drugs on the PPI deficit of animal models of schizophrenia, with greater focus on the SHR (Spontaneously Hypertensive Rats) strain, and on the future prospects resulting from these findings.en
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Dept Psychiat, Interdisciplinary Lab Clin Neurosci, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Dept Pharmacol, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Dept Neurosci & Behav, Ribeirao Preto, Brazil
dc.description.affiliationNatl Inst Translat Med INCT TM, CNPq, Ribeirao Preto, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Dept Psychiat, Interdisciplinary Lab Clin Neurosci, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Dept Pharmacol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo-FAPESP
dc.description.sponsorshipConselho Nacional do Desenvolvimento Cientifico e Tecnologico-CAPES
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.3389/fphar.2016.00303
dc.identifier.citationFrontiers In Pharmacology. Lausanne, v. 7, p. -, 2016.
dc.identifier.doi10.3389/fphar.2016.00303
dc.identifier.issn1663-9812
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/50972
dc.identifier.wosWOS:000382714800001
dc.language.isoeng
dc.publisherFrontiers Media Sa
dc.rightsAcesso restrito
dc.subjectprepulse inhibition of startle reflexen
dc.subjectanimal modelsen
dc.subjectschizophreniaen
dc.subjectcannabidiolen
dc.subjectendocannabinoid systemen
dc.subjectSHR strainen
dc.titleCannabidiol, among Other Cannabinoid Drugs, Modulates Prepulse Inhibition of Startle in the SHR Animal Model: Implications for Schizophrenia Pharmacotherapyen
dc.typeRevisão
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