Chitosan Cross-Linked Pentasodium Tripolyphosphate Micro/Nanoparticles Produced by Ionotropic Gelation

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dc.citation.issue1
dc.citation.volume18
dc.contributor.authorSeverino, Patricia
dc.contributor.authorSilva, Classius F. da [UNIFESP]
dc.contributor.authorda Silva, Mariana A.
dc.contributor.authorSantana, Maria H. A.
dc.contributor.authorSouto, Eliana B.
dc.coverageNew Delhi
dc.date.accessioned2020-11-03T14:40:27Z
dc.date.available2020-11-03T14:40:27Z
dc.date.issued2016
dc.description.abstractChitosan cross-linked pentasodium tripolyphosphate particles were produced by ionotropic gelation. The aim of this study was to evaluate the influence of the molar mass and deacetylation degree of chitosan and of the concentration of pentasodium tripolyphosphate in the production of chitosan micro/nanoparticles. The obtained charge ratio (R +/-), mean particle size, surface electrical charge, polydispersity index, and tendency of particle aggregation were selected as dependent variables. Results demonstrated that stable particles exhibited a high zeta potential value, between +62 and +68 mV. Particles were produced in different size ranges controlling the R +/- between the positively charged chitosan and negatively charged pentasodium tripolyphosphate. Chitosan micro/nanoparticles were successfully prepared via the ionic gelation method controlling R +/-, therefore the association of an active ingredient to a micro/nanoparticle allows the molecule to intimately interact with specific structures, to overcome barriers and to prolong its residence time in the target. Chitosan cross-linked pentasodium tripolyphosphate particles are expected to be a good approach for active ingredients formulation in the agrofood sector and related industries.en
dc.description.affiliationUniv Campinas UNICAMP, Sch Chem Engn, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUniv Tiradentes, Ave Murilo Dantas 300, BR-49010390 Aracaju, Brazil
dc.description.affiliationInst Technol & Res, Ave Murilo Dantas 300, BR-49010390 Aracaju, Brazil
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Sch Chem Engn, BR-09972270 Diadema, SP, Brazil
dc.description.affiliationUniv Coimbra FFUC, Fac Pharm, Dept Pharmaceut Technol, Polo Ciencias Saude, P-3000548 Coimbra, Portugal
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Sch Chem Engn, BR-09972270 Diadema, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP/Brazil)
dc.description.sponsorshipConselho Nacional de Pesquisa (CNPq, Brazil)
dc.description.sponsorshipFCT (Fundacao para a Ciencia e a Tecnologia) from the Portuguese Ministry of Education and Science
dc.description.sponsorshipEuropean Fund (FEDER)
dc.description.sponsorshipEuropean Fund (COMPETE)
dc.description.sponsorshipIDEuropean Fund (FEDER): PTDC/SAU-FAR/113100/2009
dc.description.sponsorshipIDEuropean Fund (COMPETE): PTDC/SAU-FAR/113100/2009
dc.format.extent49-54
dc.identifierhttps://doi.org/10.1007/s12355-014-0360-z
dc.identifier.citationSugar Tech. New Delhi, v. 18, n. 1, p. 49-54, 2016.
dc.identifier.doi10.1007/s12355-014-0360-z
dc.identifier.issn0972-1525
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58579
dc.identifier.wosWOS:000371440300006
dc.language.isoeng
dc.publisherSpringer India
dc.relation.ispartofSugar Tech
dc.rightsAcesso aberto
dc.subjectChitosanen
dc.subjectPentasodium tripolyphosphateen
dc.subjectIonotropic gelationen
dc.subjectCross-linkingen
dc.subjectPolysaccharideen
dc.titleChitosan Cross-Linked Pentasodium Tripolyphosphate Micro/Nanoparticles Produced by Ionotropic Gelationen
dc.typeArtigo
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