Validation of the ACR/EULAR classification criteria for systemic sclerosis in patients with early scleroderma

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dc.citation.issue11
dc.citation.volume37
dc.contributor.authorAraujo, Farley Carvalho [UNIFESP]
dc.contributor.authorCamargo, Cintia Zumstein [UNIFESP]
dc.contributor.authorKayser, Cristiane [UNIFESP]
dc.coverageHeidelberg
dc.date.accessioned2020-09-01T13:21:31Z
dc.date.available2020-09-01T13:21:31Z
dc.date.issued2017
dc.description.abstractThe aim of this study was to validate the 2013 ACR/EULAR classification criteria for systemic sclerosis (SSc) in patients with SSc, including patients with early SSc. Fifty-six consecutive patients with early SSc (2001 LeRoy and Medsger criteria), 122 patients with established SSc (1980 ACR classification criteria), and 141 patients with SSc-like disorders were included in this cross-sectional study. The diagnostic performance of the 2013 ACR/EULAR criteria was compared with the 1980 ACR criteria in several subsets of patients. The performance of individual variables was also obtained. Receiver operating characteristic (ROC) curves and optimal cut-off values were computed. The sensitivity and specificity in the whole cohort of 178 SSc patients were 77.6 and 98.5%, respectively, using the 2013 ACR/EULAR criteria and 68.5 and 100%, respectively, using the 1980 ACR criteria. Twenty-eight percent of the patients with early SSc met the 2013 ACR/EULAR criteria. Among the patients with early SSc, 53% of those who had Raynaud's phenomenon, abnormal capillaroscopy and positive SSc-related antibodies met the 2013 ACR/EULAR criteria. The area under the ROC curve was 0.975 (95% confidence interval 0.962-0.987). The best cut-off value for the total score was >= 8 (sensitivity 82%; specificity 97.9%). The individual variables with the highest specificity values were proximal skin thickening, sclerodactyly (specificity 100%), telangiectasia and SSc-related antibodies (specificity 98.6%). Raynaud's phenomenon had the best sensitivity (99.4%) but had low specificity (4.2%). In conclusion, the 2013 ACR/EULAR classification criteria showed high accuracy and increased sensitivity in the classification of patients with early SSc.en
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Rheumatol Div, Rua Botucatu 740,3 Andar, BR-04023062 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Rheumatol Div, Rua Botucatu 740,3 Andar, BR-04023062 Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent1825-1833
dc.identifierhttp://dx.doi.org/10.1007/s00296-017-3787-1
dc.identifier.citationRheumatology International. Heidelberg, v. 37, n. 11, p. 1825-1833, 2017.
dc.identifier.doi10.1007/s00296-017-3787-1
dc.identifier.issn0172-8172
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58322
dc.identifier.wosWOS:000413252700008
dc.language.isoeng
dc.publisherSpringer Heidelberg
dc.relation.ispartofRheumatology International
dc.rightsAcesso aberto
dc.subjectSystemic sclerosisen
dc.subjectDiagnosisen
dc.subjectACR/EULAR criteriaen
dc.titleValidation of the ACR/EULAR classification criteria for systemic sclerosis in patients with early sclerodermaen
dc.typeArtigo
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