Epitranscriptome machinery in Trypanosomatids: new players on the table?

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dc.contributor.authorMaran, Suellen Rodrigues [UNIFESP]
dc.contributor.authorPitta, João Luiz de Lemos Padilha
dc.contributor.authorVasconcelos, Crhisllane Rafaele dos Santos
dc.contributor.authorMcDermott, Suzanne M.
dc.contributor.authorRezende, Antonio Mauro
dc.contributor.authorMoretti, Nilmar Silvio
dc.contributor.authorLatteshttp://lattes.cnpq.br/2131472726202687pt_BR
dc.date.accessioned2021-11-29T16:25:15Z
dc.date.available2021-11-29T16:25:15Z
dc.date.issued2021
dc.description.abstractTrypanosoma and Leishmania parasites cause devastating tropical diseases resulting in serious global health consequences. These organisms have complex life cycles with mammalian hosts and insect vectors. The parasites must, therefore, survive in dif- ferent environments, demanding rapid physiological and metabolic changes. These responses depend upon regulation of gene expression, which primarily occurs post- transcriptionally. Altering the composition or conformation of RNA through nucleotide modifications is one posttranscriptional mechanism of regulating RNA fate and func- tion, and modifications including N6-methyladenosine (m6A), N1-methyladenosine (m1A), N5-methylcytidine (m5C), N4-acetylcytidine (ac4C), and pseudouridine (Ψ), dynamically regulate RNA stability and translation in diverse organisms. Little is known about RNA modifications and their machinery in Trypanosomatids, but we hypothesize that they regulate parasite gene expression and are vital for survival. Here, we identified Trypanosomatid homologs for writers of m1A, m5C, ac4C, and Ψ and analyze their evolutionary relationships. We systematically review the evidence for their functions and assess their potential use as therapeutic targets. This work provides new insights into the roles of these proteins in Trypanosomatid parasite bi- ology and treatment of the diseases they cause and illustrates that Trypanosomatids provide an excellent model system to study RNA modifications, their molecular, cel- lular, and biological consequences, and their regulation and interplay.pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipIDFAPESP: 2018/09948-0pt_BR
dc.description.sponsorshipIDFAPESP: 2019/13765-1pt_BR
dc.description.sponsorshipIDCNPq: 424729/2018pt_BR
dc.identifier.doi10.1111/mmi.14688
dc.identifier.urihttps://hdl.handle.net/11600/62328
dc.languageengpt_BR
dc.publisherWileypt_BR
dc.relation.ispartofMolecular Microbiologypt_BR
dc.rightsAcesso restritopt_BR
dc.subjectac4Cpt_BR
dc.subjectm1Apt_BR
dc.subjectm5Cpt_BR
dc.subjectPseudouridinept_BR
dc.subjectRNA modificationpt_BR
dc.titleEpitranscriptome machinery in Trypanosomatids: new players on the table?pt_BR
dc.typeArtigopt_BR
unifesp.campusEscola Paulista de Medicina (EPM)pt_BR
unifesp.departamentoMicrobiologia, Imunologia e Parasitologiapt_BR
unifesp.graduateProgramMicrobiologia e Imunologiapt_BR
unifesp.knowledgeAreaOutrapt_BR
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