Adaptive immunity is related to coronary artery disease severity after acute coronary syndrome in subjects with metabolic syndrome

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dc.contributor.authorIzar, Maria C. [UNIFESP]
dc.contributor.authorFonseca, Henrique A. [UNIFESP]
dc.contributor.authorPinheiro, Luiz F. [UNIFESP]
dc.contributor.authorMonteiro, Carlos M. [UNIFESP]
dc.contributor.authorPovoa, Rui M. [UNIFESP]
dc.contributor.authorMonteiro, Andrea M.
dc.contributor.authorFigueiredo-Neto, Antonio M.
dc.contributor.authorGidlund, Magnus A.
dc.contributor.authorFonseca, Francisco A. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T14:31:06Z
dc.date.available2016-01-24T14:31:06Z
dc.date.issued2013-01-01
dc.description.abstractMetabolic syndrome (MetS) is an inflammatory state associated with high coronary disease risk. Inflammation and adaptive immunity modulate atherosclerosis and plaque instability. We examined early changes in anti-oxidized low-density lipoprotein (LDL) (anti-oxLDL) autoantibodies (Abs) in patients with MetS after an acute coronary syndrome (ACS). Patients of both genders (n=116) with MetS were prospectively included after an acute myocardial infarction (MI) or hospitalization due to unstable angina. Anti-oxLDL Abs (IgG class) were assayed at baseline, three and six weeks after ACS. the severity of coronary disease was evaluated by the Gensini score. We observed a decrease in anti-oxLDL Abs titers (p<0.002 vs. baseline), mainly in males (p=0.01), in those under 65 y (p=0.03), and in subjects with Gensini score above median (p=0.04). in conclusion, early decrease in circulating anti-oxLDL Abs is associated with coronary disease severity among subjects with MetS.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Med, Div Cardiol, BR-04039030 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Immunol, Inst Biomed Sci, BR-05508 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Natl Inst Complex Fluids, Inst Phys, BR-05508 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Med, Div Cardiol, BR-04039030 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipNational Institute of Science and Technology-Nanomaterials for Integrated Markers (INCT-INAMI), Recife, PE, Brazil
dc.description.sponsorshipIDFAPESP: 2004/00325-8
dc.format.extent32-39
dc.identifierhttp://dx.doi.org/10.1177/1479164112443374
dc.identifier.citationDiabetes & Vascular Disease Research. London: Sage Publications Ltd, v. 10, n. 1, p. 32-39, 2013.
dc.identifier.doi10.1177/1479164112443374
dc.identifier.issn1479-1641
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35854
dc.identifier.wosWOS:000314327900005
dc.language.isoeng
dc.publisherSage Publications Ltd
dc.relation.ispartofDiabetes & Vascular Disease Research
dc.rightsAcesso restrito
dc.rights.licensehttp://www.uk.sagepub.com/aboutus/openaccess.htm
dc.subjectAcute coronary syndrome (ACS)en
dc.subjectautoantibodies (Abs)en
dc.subjectmetabolic syndrome (MetS)en
dc.subjectoxidized low-density lipoprotein (oxLDL)en
dc.titleAdaptive immunity is related to coronary artery disease severity after acute coronary syndrome in subjects with metabolic syndromeen
dc.typeArtigo
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