Mitochondrial alterations and apoptosis in smooth muscle from aged rats

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dc.contributor.authorLopes, Guiomar Silva [UNIFESP]
dc.contributor.authorMora, Oswaldo Alves [UNIFESP]
dc.contributor.authorCerri, Paulo Sergio [UNIFESP]
dc.contributor.authorFaria, Flavio Paulo de [UNIFESP]
dc.contributor.authorJurkiewicz, Neide Hyppolito [UNIFESP]
dc.contributor.authorJurkiewicz, Aron
dc.contributor.authorSmaili, Soraya Soubhi [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUNESP
dc.date.accessioned2016-01-24T12:37:26Z
dc.date.available2016-01-24T12:37:26Z
dc.date.issued2004-10-04
dc.description.abstractWe studied changes in mitochondrial morphology and function in the smooth muscle of rat colon. Under confocal microscopy, tissues loaded with potentiometric dye displayed rapid and spontaneous depolarization. Cyclosporin A (CsA), inhibitor of the permeability transition pore (PTP), caused an increase in mitochondrial membrane potential (DeltaPsi(m)) in tissues from adult young animals. in aged rats these changes were not observed. This suggests that physiological activation of PTP in aged rats is reduced. Electron microscopy showed alterations of the mitochondrial ultrastructure in tissues from aged rats involving a decreased definition of the cristae and fragmentation of the mitochondrial membranes. We also detected an increase in apoptotic cells in the smooth muscle from aged animals. Our results show that the aging process changes PTP activity, the ability to maintain DeltaPsi(m) and mitochondrial morphology. It is suggested that these can be associated with mitochondrial damage and cell death. (C) 2004 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Nat Inst Pharmacol, Dept Pharmacol, BR-04044020 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Morphol, São Paulo, Brazil
dc.description.affiliationUNESP, Sch Dent, Dept Morphol, Araraquara, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Nat Inst Pharmacol, Dept Pharmacol, BR-04044020 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Morphol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent187-194
dc.identifierhttp://dx.doi.org/10.1016/j.bbabio.2004.05.011
dc.identifier.citationBiochimica Et Biophysica Acta-bioenergetics. Amsterdam: Elsevier B.V., v. 1658, n. 3, p. 187-194, 2004.
dc.identifier.doi10.1016/j.bbabio.2004.05.011
dc.identifier.fileWOS000224338200002.pdf
dc.identifier.issn0005-2728
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/27978
dc.identifier.wosWOS:000224338200002
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBiochimica Et Biophysica Acta-bioenergetics
dc.rightsAcesso aberto
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectmitochondriaen
dc.subjectcalciumen
dc.subjectsmooth muscleen
dc.subjectagingen
dc.subjectmitochondrial dysfunctionen
dc.titleMitochondrial alterations and apoptosis in smooth muscle from aged ratsen
dc.typeArtigo
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