Protein acetylation in the critical biological processes in protozoan parasites
| dc.contributor.author | Maran, Suellen Rodrigues [UNIFESP] | |
| dc.contributor.author | Fleck, Krista | |
| dc.contributor.author | Monteiro-Teles, Natália Melquie | |
| dc.contributor.author | Isebe, Tony | |
| dc.contributor.author | Walrad, Pegine | |
| dc.contributor.author | Jeffers, Victoria | |
| dc.contributor.author | Cestari, Igor | |
| dc.contributor.author | Vasconcelos, Elton J.R. | |
| dc.contributor.author | Moretti, Nilmar [UNIFESP] | |
| dc.contributor.authorLattes | http://lattes.cnpq.br/2131472726202687 | pt_BR |
| dc.date.accessioned | 2021-11-29T16:48:26Z | |
| dc.date.available | 2021-11-29T16:48:26Z | |
| dc.date.issued | 2021 | |
| dc.description.abstract | Protein lysine acetylation has emerged as a major regulatory post-translational modi!cation in different organisms, present not only on histone proteins affecting chromatin structure and gene expression but also on nonhistone proteins involved in several cellular processes. The same scenario was observed in protozoan para- sites after the description of their acetylomes, indicating that acetylation might regulate crucial biological processes in these parasites. The demonstration that glycolytic enzymes are regulated by acetylation in protozoans shows that this modi!cation might regulate several other processes implicated in parasite survival and adaptation during the life cycle, opening the chance to explore the regulatory acetylation machinery of these parasites as drug targets for new treatment development. | pt_BR |
| dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | pt_BR |
| dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | pt_BR |
| dc.description.sponsorshipID | FAPESP: 2018/09948-0 | pt_BR |
| dc.description.sponsorshipID | FAPESP: 2019/13765-1 | pt_BR |
| dc.description.sponsorshipID | CNPq: 424729/2018 | pt_BR |
| dc.identifier.doi | https://doi.org/10.1016/j.pt.2021.04.008 | pt_BR |
| dc.identifier.uri | https://hdl.handle.net/11600/62329 | |
| dc.language | eng | pt_BR |
| dc.publisher | Cell Press | pt_BR |
| dc.relation.ispartof | Trends in Parasitology | pt_BR |
| dc.rights | Acesso restrito | pt_BR |
| dc.subject | Acetylation | pt_BR |
| dc.subject | T brucei | pt_BR |
| dc.subject | T cruzi | pt_BR |
| dc.subject | Malaria | pt_BR |
| dc.title | Protein acetylation in the critical biological processes in protozoan parasites | pt_BR |
| dc.type | Artigo | pt_BR |
| unifesp.campus | Escola Paulista de Medicina (EPM) | pt_BR |
| unifesp.departamento | Microbiologia, Imunologia e Parasitologia | pt_BR |
| unifesp.graduateProgram | Microbiologia e Imunologia | pt_BR |
| unifesp.knowledgeArea | Outra | pt_BR |