Vitex agnus castus for premenstrual syndrome and premenstrual dysphoric disorder: a systematic review

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dc.citation.issue6
dc.citation.volume20
dc.contributor.authorCerqueira, Raphael O. [UNIFESP]
dc.contributor.authorFrey, Benicio N.
dc.contributor.authorLeclerc, Emilie [UNIFESP]
dc.contributor.authorBrietzke, Elisa [UNIFESP]
dc.coverageWien
dc.date.accessioned2020-09-01T13:21:12Z
dc.date.available2020-09-01T13:21:12Z
dc.date.issued2017
dc.description.abstractThe objective of this study was to evaluate whether Vitex agnus castus is a safe and effective treatment for PMS and premenstrual dysphoric disorder (PMDD) and to discuss the implications of these findings for clinical practice. A systematic review of literature was conducted using PubMed and Scielo databases. The inclusion criteria were randomized controlled trials (RCT) using V. agnus castus in individuals with PMS or PMDD that compared this intervention with placebo or an active comparator and included a description of blinding and dropouts/withdrawals. The search was conducted by two independent investigators who reached consensus on the included trials. A total of eight RCTs were included in this study. Most studies focused on PMS, and the diagnostic criteria of PMS and PMDD changed over the years. Three different preparations of V. agnus castus (VAC) were tested, and there was significant variability in the measurement of treatment outcomes between the studies. Nevertheless, all eight studies were positive for VAC in the treatment of PMS or PMDD and VAC was overall well tolerated. Main limitations were differences in definition of diagnostic criteria, the instruments used as main outcome measures, and different preparations of VAC extracts limit the comparison of results between studies. In conclusion, the RCTs using VAC for treatment of PMS/PMDD suggested that the VAC extract is a safe and efficacious alternative to be considered for the treatment of PMS/PMDD symptoms.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychiat, Res Grp Behav & Mol Neurosci Bipolar Disorder, Rua Borges Lagoa,570-10th Floor,Vila Clementino, BR-04038000 Sao Paulo, Brazil
dc.description.affiliationMcMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON, Canada
dc.description.affiliationSt Josephs Healthcare, Womens Hlth Concerns Clin, Hamilton, ON, Canada
dc.description.affiliationSt Josephs Healthcare, Mood Disorders Program, Hamilton, ON, Canada
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psychiat, Res Grp Behav & Mol Neurosci Bipolar Disorder, Rua Borges Lagoa,570-10th Floor,Vila Clementino, BR-04038000 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent713-719
dc.identifierhttp://dx.doi.org/10.1007/s00737-017-0791-0
dc.identifier.citationArchives Of Womens Mental Health. Wien, v. 20, n. 6, p. 713-719, 2017.
dc.identifier.doi10.1007/s00737-017-0791-0
dc.identifier.issn1434-1816
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58123
dc.identifier.wosWOS:000415731700001
dc.language.isoeng
dc.publisherSpringer Wien
dc.relation.ispartofArchives Of Womens Mental Health
dc.rightsAcesso aberto
dc.subjectVitex agnus castusen
dc.subjectChasteberryen
dc.subjectPremenstrual syndromeen
dc.subjectPremenstrual dysphoric disorderen
dc.subjectTreatmenten
dc.titleVitex agnus castus for premenstrual syndrome and premenstrual dysphoric disorder: a systematic reviewen
dc.typeArtigo
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